alexa Pentoxifylline Explores New Horizons in Treatment of Ha
ISSN: 0974-8369

Biology and Medicine
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Hypothesis

Pentoxifylline Explores New Horizons in Treatment of Hashimoto Thyroiditis

Arsalan Azimi*

Doctor of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

*Corresponding Author:
Arsalan Azimi
Doctor of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Tel: +989171066597
E-mail: [email protected]

Received date: February 01, 2016; Accepted date: February 20, 2016; Published date: February 25, 2016

Citation: Azimi A (2016) Pentoxifylline Explores New Horizons in Treatment of Hashimoto Thyroiditis. Biol Med (Aligarh) 8:293. doi:10.4172/0974-8369.1000293

Copyright: © 2016 Azimi A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Hashimoto Thyroiditis is an autoimmune disease and the most common cause of hypothyroidism in developed countries. As the disease initiates unusual thyroidal antigens are exposed to the immune system. The immune system sensitizes to those antigens and creates a cell mediated autoimmune response against thyroid gland. Inflammatory cells infiltrate within thyroid follicles and destruct the follicles by inflicting oxidative stress and inducing apoptosis. The inflammatory process also reduces sensitivity of thyrocytes to Thyroid Stimulating Hormone (TSH). As the disease progresses and the follicles degrade, fibrotic tissue replaces the follicles until the whole gland becomes fibrotic. Pentoxiflline could inhibit autoimmune destruction of thyrocytes, suppress cell mediated immune response against thyroid, decrease oxidative damage to thyrocytes, increase sensitivity of thyrocytes to TSH and hinder fibrotic degeneration of thyroid. Thereby PTX could cure HT and alleviate symptoms of hypothyroidism.

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