alexa pEPI for Gene Therapy Non viral episomes and their Appl
ISSN: 2157-7013

Journal of Cell Science & Therapy
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Research Article

pEPI for Gene Therapy Non viral episomes and their Application in Somatic Gene Therapy

Claudia Hagedorn* and Hans J. Lipps
Centre for Biomedical Education and Research, Institute of Cell Biology, University Witten/Herdecke, Germany
Corresponding Author : Claudia Hagedorn
Centre for Biomedical Education and Research
Institute of Cell Biology, University Witten/Herdecke
Stockumer Str. 10, 58453 Witten, Germany
Tel: +49 2302 926144
E-mail: [email protected]
Received August 19, 2011; Accepted October 10, 2011; Published October 12, 2011
Citation: Hagedorn C, Lipps HJ (2011) pEPI for Gene Therapy: Non-viral episomes and their Application in Somatic Gene Therapy. J Cell Sci Ther S6:001. doi: 10.4172/2157-7013.S6-001
Copyright: © 2011 Hagedorn C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Nowadays, in most gene therapy trials virus based vectors are used because of their high efficiency. Nevertheless, safety risks like transformation of the cell by viral proteins, insertional mutagenesis, or innate immune reactions cannot be excluded. Basing on the idea of an ideal vector for gene therapy that is highly efficient but lacks these safety risks, non viral vectors systems represent an attractive alternative. With the construction of the non viral, S/ MAR based vector pEPI at the end of the last century, a first step towards non viral gene therapy has been made. S/MAR based vectors do not contain any viral elements, do not integrate and show stable transgene expression in the targeted cell or organism. Within the last decade, S/MAR based vectors were further improved and modified, and find now broad application in basic research and also become more and more recognized in gene therapeutic and clinical trials.

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