alexa Performances of SD Bioline Malaria Ag-P.F/Pan RDT for the Diagnosis of Malaria in Febrile Patients Living In Gabon, Central Africa | OMICS International
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Malaria Control & Elimination
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Research Article

Performances of SD Bioline Malaria Ag-P.F/Pan RDT for the Diagnosis of Malaria in Febrile Patients Living In Gabon, Central Africa

Bouyou Akotet MK1,2*, Nkare CA2, Offouga Mbouoronde C1,2and Mawili-Mboumba DP1,2

1Department of Parasitology-Mycology, Faculty of Medicine, University of the Health Sciences, Libreville, Gabon.

2Malaria Clinical and Operational Research Unit, Regional Hospital of Melen, Estuaire, Gabon.

*Corresponding Author:
Marielle Karine Bouyou Akotet
Department of Parasitology-Mycology
Faculty of Medicine, University of the Health Sciences
Libreville, Gabon. BP 4009 Libreville, Gabon
Tel: 00241017048 96
Fax: 0024101704896
E-mail: [email protected]

Received Date: August 06, 2014; Accepted Date: September 27, 2014; Published Date: October 04, 2014

Citation: Akotet BMK, Nkare CA, Mbouoronde OC, Mawili-Mboumba DP (2014) Performances of SD Bioline Malaria Ag-P.F/Pan RDT for the Diagnosis of Malaria in Febrile Patients Living In Gabon, Central Africa. Malar Chemoth Cont Elimination 3:125. doi: 10.4172/2090-2778.1000125

Copyright: © 2014 Akotet BMK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

 The SD Bioline malaria Ag- Pf/Pan performances were evaluated for malaria species detection in 215 febrile patients living in Gabon, using microscopy as gold standard. Malaria parasites were identified in 94 (43.7%) individuals by microscopy, and 104 (48.4%) patients tested positive by the RDT. The SD Bioline Ag-Pf/Pan global sensitivity was 96.8%. All the non-falciparum malaria species infections were correctly diagnosed by the rapid test. The specificity was of 89.3% and the false positive (FP) rate of 12.5%. The test sensitivity significantly increased with parasitaemia, being of 88.9% for parasite density below 100/ µL and 98.5% at density higher than 500 parasites/ µL (p<0.01). Among the patients with a negative blood smear, the proportion of FP results was 21.0% in those previously-treated with an antimalarial drug before the consultation, and 8.8% in individuals without self-medication. SD Bioline Ag-Pf/ Pan RDT represents a good alternative to microscopy for the diagnosis of Plasmodium spp infection.

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