Perilla Derived Compounds Mediate Human TRPA1 Channel Activity
- *Corresponding Author:
- Alberto Maria Cattaneo
Department of Food, Environmental and Nutritional Sciences
Università degli Studi di Milano, Via Celoria, 2 20133, Milan (MI) - Italy
Tel: +39 392 2939008
E-mail: [email protected]
Received Date: January 20, 2017; Accepted Date: February 01, 2017; Published Date: February 06, 2017
Citation: Cattaneo AM, Bobkov YV, Corey EA, Borgonovo G, Bassoli A (2017) Perilla Derived Compounds Mediate Human TRPA1 Channel Activity. Med Aromat Plants (Los Angel) 6: 283. doi: 10.4172/2167-0412.1000283
Copyright: © 2017 Cattaneo AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Compounds from food plants affecting the somatosensory system, like Perilla frutescens (L.), are well known for their flavoring, pharmacological and medical properties. Yet the exact mechanisms underlying their activity are still poorly understood. Transient Receptor Potential (TRP) channels involved in chemestetic sensations likely represent some of the primary targets for these compounds. Using a heterologous expression system and calcium imaging we show that a number of Perilla derived compounds (S-(-)-1,8-p-menthadiene-7-al (perillaldehyde, PA); 3-(4-methyl- 1-oxopentyl)furan (perillaketone, PK); 1,2,4-trimethoxy-5-[(E)-prop-1-enyl]benzene (α-asarone, ASA)) and synthetic compounds derivative from Perilla (3-(4-methoxy-phenyl)-1-furan-2-yl-propenone (PK-16) and 3-(4-chloro-phenyl)- 1-furan-2-yl-propenone (PK-18)) are capable of activating the human TRP Ankyrin family channel (h-TRPA1). The compounds tested appear to be partial agonists of the channel with the potency sequence (EC50, μM): PK- 16(107.7)>PA (160.5)>ASA(210.9)>PK(350). Our findings provide important insight into the functional properties of the compounds derived from P. frutescens and reveal new perspectives for the design of tools for pharmaceutical, agricultural and food industry applications.