alexa Perioperative White Blood Cell Count as a Marker for Patient and Graft Survival after Orthotopic Liver Transplantation
ISSN: 2475-3181

Journal of Hepatology and Gastrointestinal disorders
Open Access

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Research Article

Perioperative White Blood Cell Count as a Marker for Patient and Graft Survival after Orthotopic Liver Transplantation

Helfritz FA1, Lehner F1, Manns MP2,3, Ciesek S2,3* and Klempnauer J1

1Department of General-, Visceral and Transplant Surgery, Hannover Medical School, Germany

2Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany

3Integrated Researches and Treatment Centre – Transplantation (IFB-Tx), Germany

Corresponding Author:
Sandra Ciesek
Department of Gastroenterology, Hepatology and Endocrinology
Medical School Hannover, Carl Neuberg Str. 1, 30625 Hannover, Germany
Tel: +49 511 532-4585
Fax: +49 511 532-4896
E-mail: [email protected]

Received Date: November 17, 2015 Accepted Date: December 07, 2015 Published Date: December 14, 2015

Citation: Helfritz FA, Lehner F, Manns MP, Ciesek S, Klempnauer J (2015) Perioperative White Blood Cell Count as a Marker for Patient and Graft Survival after Orthotopic Liver Transplantation. J Hepatol Gastroint Dis 1:106. doi:10.4172/2475-3181.1000106

Copyright: © 2015 Helfritz FA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Orthotopic liver transplantation (OLT) is a standard procedure in end stage liver disease. However, recipients of OLT have a 10-15% risk to die within one year after transplantation. We evaluated whether different parameters of infection including inflammatory markers and white blood cells (WBC) predict post-OLT mortality, graft survival and rate of acute rejection.
Methods: We collected clinical and laboratory data of 102 patients undergoing liver transplantation between 2011 and 2012 Hannover Medical School. Patients were stratified by i) patient survival, ii) graft survival and iii) episode of rejection(s) and were followed from OLT for one year. Laboratory data of peritransplant period (0-4 days after OLT) were analyzed.
Results: Inflammatory markers like CRP and procalcitonin had no significant effect on one-year patient or graft survival after OLT (p=0.3 or p=0.8 respectively). Interestingly, WBC early after OLT was a prognostic marker for patients (p=0.019) and graft survival (p=0.03). Importantly, white blood cell count early after OLT was independent from rate of acute rejection episodes. White blood cell count >20.000/μl within the first four days after OLT was associated with a higher patient and graft mortality. Patient mortality was 30% (WBC >20.000/μl) in comparison to 13% (WBC <20.000/μl). These results were independent from the underlying liver disease or type of immunosuppressive regimen.
Conclusions: These data demonstrate that white blood cell count >20.000/μl early after OLT is a cheap prognostic marker for patient and graft survival, while perioperative procalcitonin and CRP levels have no influence.


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