alexa Perioperative White Blood Cell Count as a Marker for Patient and Graft Survival after Orthotopic Liver Transplantation | OMICS International | Abstract
ISSN: 2475-3181

Journal of Hepatology and Gastrointestinal disorders
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Perioperative White Blood Cell Count as a Marker for Patient and Graft Survival after Orthotopic Liver Transplantation

Helfritz FA1, Lehner F1, Manns MP2,3, Ciesek S2,3* and Klempnauer J1

1Department of General-, Visceral and Transplant Surgery, Hannover Medical School, Germany

2Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany

3Integrated Researches and Treatment Centre – Transplantation (IFB-Tx), Germany

Corresponding Author:
Sandra Ciesek
Department of Gastroenterology, Hepatology and Endocrinology
Medical School Hannover, Carl Neuberg Str. 1, 30625 Hannover, Germany
Tel: +49 511 532-4585
Fax: +49 511 532-4896
E-mail: [email protected]

Received Date: November 17, 2015 Accepted Date: December 07, 2015 Published Date: December 14, 2015

Citation: Helfritz FA, Lehner F, Manns MP, Ciesek S, Klempnauer J (2015) Perioperative White Blood Cell Count as a Marker for Patient and Graft Survival after Orthotopic Liver Transplantation. J Hepatol Gastroint Dis 1:106. doi:10.4172/2475-3181.1000106

Copyright: © 2015 Helfritz FA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Orthotopic liver transplantation (OLT) is a standard procedure in end stage liver disease. However, recipients of OLT have a 10-15% risk to die within one year after transplantation. We evaluated whether different parameters of infection including inflammatory markers and white blood cells (WBC) predict post-OLT mortality, graft survival and rate of acute rejection.
Methods: We collected clinical and laboratory data of 102 patients undergoing liver transplantation between 2011 and 2012 Hannover Medical School. Patients were stratified by i) patient survival, ii) graft survival and iii) episode of rejection(s) and were followed from OLT for one year. Laboratory data of peritransplant period (0-4 days after OLT) were analyzed.
Results: Inflammatory markers like CRP and procalcitonin had no significant effect on one-year patient or graft survival after OLT (p=0.3 or p=0.8 respectively). Interestingly, WBC early after OLT was a prognostic marker for patients (p=0.019) and graft survival (p=0.03). Importantly, white blood cell count early after OLT was independent from rate of acute rejection episodes. White blood cell count >20.000/μl within the first four days after OLT was associated with a higher patient and graft mortality. Patient mortality was 30% (WBC >20.000/μl) in comparison to 13% (WBC <20.000/μl). These results were independent from the underlying liver disease or type of immunosuppressive regimen.
Conclusions: These data demonstrate that white blood cell count >20.000/μl early after OLT is a cheap prognostic marker for patient and graft survival, while perioperative procalcitonin and CRP levels have no influence.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version