alexa Peripheral Blood B cell Subsets and BAFF/APRIL Levels and their Receptors are Disturbed in Rheumatoid Arthritis but not in Ankylosing Spondylitis | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Peripheral Blood B cell Subsets and BAFF/APRIL Levels and their Receptors are Disturbed in Rheumatoid Arthritis but not in Ankylosing Spondylitis

Béatrice Gaugler1-3, Caroline Laheurte2,4, Ewa Bertolini5, Aurore Pugin4, Daniel Wendling5,6, Philippe Saas1-4*, Éric Toussirot4-7* on behalf of CBT-506
1INSERM UMR1098, Besançon, F-25020, France
2EFS Bourgogne Franche-Comté, UMR1098, Plateforme de BioMonitoring, F-25020 Besançon Cedex, France
3Université de Franche-Comté, UMR1098, Besançon, F-25020, France
4Centre Investigation Clinique Biothérapie INSERM CBT 506, CHRU, Besançon, France
5Service de Rhumatologie, CHRU, Besançon, France
6EA 4166 Agents Pathogènes et Inflammation Université de Franche Comté, Besançon, France
7Département Universitaire de Thérapeutique, Université de Franche Comté, Besançon, France
Corresponding Author : Eric Toussirot
Professsor, Centre d’Investigation Clinique Biothérapie CBT-506
bâtiment St Joseph, CHRU Place St Jacques
25000 Besançon, France
Tel: 33 3 81 21 89 97
Fax: 33 3 81 21 85 22
E-mail: [email protected]
  Philippe Saas
Professor, INSERM UMR1098
EFS Bourgogne Franche-Comté
1 Bd Fleming, 25000 Besançon, France
Tel: 33 3 81 615 615
Fax: 33 3 81 615 800
E-mail: [email protected]
Received: August 13, 2013; Accepted: September 11, 2013; Published: September 18, 2013
Citation: Gaugler B, Laheurte C, Bertolini E, Pugin A, Wendling D, et al. (2013) Peripheral Blood B cell Subsets and BAFF/APRIL Levels and their Receptors are Disturbed in Rheumatoid Arthritis but not in Ankylosing Spondylitis. J Clin Cell Immunol 4:163. doi:10.4172/2155-9899.1000163
Copyright: © 2013 Gaugler B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: To evaluate the distribution of circulating B cell subsets and their expression of BAFF/APRIL receptors (BAFF-R, TACI and BCMA) as well as circulating levels of BAFF and APRIL in patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) compared to healthy controls (HC).
Methods: 59 patients with RA, 61 patients with AS and 61 HC were evaluated. All patients were receiving traditional treatments and had not received prior biological treatment. Peripheral blood B cell subsets were assessed using multicolor flow cytometry using CD27, CD38 and IgD staining. Expression of BAFF-R, TACI and BCMA was analyzed on each cell subset.
Results: Distribution of peripheral B cells subsets was disturbed in RA compared to HC, with a decreased proportion of naïve and transitional B cells (p<0.005), whereas B cell subsets were comparable between AS and HC. Circulating BAFF did not differ between the three groups, while the ratio of BAFF/B cell number was significantly higher in RA compared to HC (p<0.001). Circulating APRIL levels were increased in RA compared to HC (p<0.001). Circulating BAFF and APRIL, and BAFF/B cell ratio did not differ between AS and HC. We also observed increased expression of BCMA, but not BAFF-R in RA, on both naïve and memory B cell subsets (post germinal center) (p<0.005), whereas TACI expression was decreased on memory B cells (p=0.001). The expression of BAFF/APRIL receptors did not differ between AS and HC.
Conclusion: Disturbances in B cell homeostasis in RA may promote B cell survival and deregulation, favoring the emergence of autoimmune B cells. Conversely, B cell homeostasis is not disrupted in AS.

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