Peripheral Bone Mineral Density and Bone Turnover in Postmenopausal Women with Type 2 DiabetesSaeed BO1*, Nixon SJ2 and Weaver JU3,4
- *Corresponding Author:
- Dr. Bakri O Saeed
Department of Clinical Biochemistry
Whittington Hospital, 5 Rufford Street, London, UK
E-mail: [email protected]
Received date: June 18, 2012; Accepted date: July 02, 2012; Published date: July 06, 2012
Citation: Saeed BO, Nixon SJ, Weaver JU (2012) Peripheral Bone Mineral Density and Bone Turnover in Postmenopausal Women with Type 2 Diabetes. J Diabetes Metab S1:007. doi: 10.4172/2155-6156.S1-007
Copyright: © 2012 Saeed BO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Several studies have suggested that diabetes affects Bone Mineral Density (BMD). In this study, we investigated the effect of type 2 diabetes mellitus (T2DM) on BMD and the rate of bone turnover in postmenopausal women.
Methods: This is a cross-sectional study, in which we measured peripheral bone density and markers of bone turnover in 60 postmenopausal women with T2DM and 48 age, alcohol intake and physical activity - matched control postmenopausal women without diabetes.
Results: BMD was significantly greater in subjects with T2DM than controls (0.51 gm/cm2 vs. 0.47 gm/cm2, p<0.01). Women with T2DM also had higher Body Mass Index (BMI) than the control group (mean: 33.7 kg/m2 vs. 26.7 kg/m2, p<0.0001). The difference in BMD between the two groups became non-significant after adjusting for the effect of BMI by multiple regression analysis (p=0.091). Osteocalcin, a marker of bone formation and three markers of bone resorption (cross-linked-N-telopeptides [NTX], C-telopeptides of type 1 collagen [CTX], and Helical peptide) were significantly reduced in T2DM compared with controls. However, the difference in the three bone resorption markers also became insignificant after adjusting for BMI.
Conclusion: This study has shown that postmenopausal women with type 2 Diabetes Mellitus apparently have higher BMD and slow bone turnover when compared with matched controls. However, the difference in BMD between the two groups became non-significant after adjusting for the effect of BMI. This study therefore does not provide evidence that T2DM per se affects bone mineral density in postmenopausal women.