Personalized Medicine in Oncology and Companion Diagnostics:Development and Challenges
- *Corresponding Author:
- Hanh La, MD
University of California
Davis Comprehensive Cancer Center, USA
E-mail: [email protected]
Received Date: April 15, 2013; Accepted Date: June 27, 2013; Published Date: July 01, 2013
Citation: La H, Cheng L, Pan CX (2013) Personalized Medicine in Oncology and Companion Diagnostics: Development and Challenges. Transl Med 3:113. doi: 10.4172/2161-1025.1000113
Copyright: © 2013 La H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Caveolae are flask-like invaginations of the plasma membrane enriched in cholesterol, sphingolipids, the marker protein caveolin and the coat protein cavin. In cardiomyocytes, multiple signaling molecules are concentrated and organized within the caveolae to mediate signaling transduction. Recent studies suggest that caveolae and caveolaeassociated signaling molecules play an important role in protecting the myocardium against ischemia-reperfusion injury. For example, cardiac-specific overexpression of caveolin-3 has been shown to lead to protection that mimics ischemic preconditioning, while the knockout of caveolin-3 abolished ischemic preconditioning. In this review, we discuss the molecular mechanisms and signaling pathways that are involved in caveolae-mediated cardioprotection, and examine the potential for caveolae as a therapeutic target for pharmaceutical intervention to treat cardiovascular disease.