Personalizing HIV Therapy, Mission Impossible?
Nils Von Hentig*
HIVCENTER, Medical Department II, Johann Wolfgang Goethe University Hospital Frankfurt, Germany
- *Corresponding Author:
- Nils Von Hentig
HIVCENTER, Medical Department II
Johann Wolfgang Goethe University
60590 Frankfurtam Main, Germany
E-mail: [email protected]
Received Date: December 21, 2012; Accepted Date: January 25, 2013; Published Date: January 30, 2013
Citation: Hentig NV (2013) Personalizing HIV Therapy, Mission Impossible? J Antivir Antiretrovir 5:012-020. doi: 10.4172/jaa.1000058
Copyright: © 2013 Hentig NV. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings. Treatment response rates range up to 90% in therapy naïve patients but decline to approximately 50% in patients who received several antiretrovirals during treatment history. Furthermore, HIV protease inhibitors (PI) and non nucleoside reverse transcriptase inhibitors (NNRTI) plasma concentrations display high inter- and intra individual variability and the therapeutic window is comparably narrow. In this therapeutic setting the personalization of dosing regimens has been suggested in many cases to tailor the ARV plasma concentrations with the intention to maximize therapy success and minimize side effects in the individual. However, personalizing therapy by modifying the dosing regimen bears the danger of losing therapeutic efficacy, increasing side effects or causing viral resistance.
This topical review identifies pharmacokinetic and pharmacodynamic models of antiretroviral therapy appraising the potential application to HIV therapy and discusses its future in the light of new drug classes and fix-dose combinations.