alexa Perspectives on Pharmacological Prevention of Pacing In
ISSN: 2168-9431

Single Cell Biology
Open Access

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Commentary

Perspectives on Pharmacological Prevention of Pacing Induced Heart Remodeling: Targeting Extracellular Matrix

Andrzej Tomasik*
Department of Cardiology in Zabrze, Medical University of Silesia in Katowice Ul. Skłodowskiej 10, 41-800 Zabrze, Poland
Corresponding Author : Andrzej Tomasik
Department of Cardiology in Zabrze
Medical University of Silesia in Katowice Ul
Skłodowskiej 10, 41- 800 Zabrze, Poland
Tel: +48 32 373 23 72
Fax: +48 32 271 10 10
Email: [email protected]
Received July 28, 2015; Accepted September 08, 2015; Published September 10, 2015
Citation: Tomasik A (2015) Perspectives on Pharmacological Prevention of Pacing Induced Heart Remodeling: Targeting Extracellular Matrix. Single Cell Biol 4:120. doi:10.4172/2168-9431.1000120
Copyright: © 2015 Tomasik. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Right ventricle apical pacing causes dyssynchronous left ventricle contraction. Dyssynchrony leads to ventricular remodeling and an overt heart failure eventually. Experimental animal studies lend the evidence that dyssynchronous contraction is accompanied by tremendous derangement in extracellular compartment with altered collagen content, activity and expression of matrix metalloproteinases and their inhibitors. The capability of some therapeutic agents like angiotensin converting enzyme inhibitors, angiotensin receptor blockers or beta blockers to prevent postinfarction left ventricle remodeling should be considered as an anti-remodeling treatment in patients with implanted pacemakers and obligatory right ventricle pacing. We summarize the evidence and rationale for such preventive management.

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