alexa PET - CT Scan Shows Decreased Severity of Autism after
ISSN: 2165-7890

Autism-Open Access
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Research Article

PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report

Alok Sharma1, Hemangi Sane2, Nandini Gokulchandran1, Prerna Badhe1, Avantika Patil2, Pooja Kulkarni2* and Amruta Paranjape2,3

1Department of Medical Services and Clinical research, NeuroGen Brain and Spine Institution, Mumbai, India

2Department of Research and Development, NeuroGen Brain and Spine Institution, Mumbai, India

3Department of Neuro Rehabilitation, NeuroGen Brain and Spine Institution, Mumbai, India

*Corresponding Author:
Kulkarni P
Neurogen Brain and Spine Institute
Stem Asia Hospital and Research Centre
Plot No. 19, Sector 40, Navi Mumbai - 400706, India
Tel: +91 9920200400
E-mail: [email protected]

Received date: February 01, 2016 Accepted date: March 02, 2016 Published date: March 09, 2016

Citation: Sharma A, Sane H, Gokulchandran N, Badhe P, Patil A, et al. (2016) PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report. Autism Open Access 6:169. doi:10.4172/2165-7890.1000169

Copyright: © 2016 Sharma A, et al. This is an open - access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



PET - CT scan has been recently utilized to detect functional abnormalities in the brain. In autism, the MRI of brain is normal hence, functional neuroimaging techniques such as Positron Emission Tomography - Computer Tomography scan of the brain should be explored. Autism is a complex neurodevelopmental disorder affecting communication, behavior and socialization. Currently, available therapeutic approaches are aimed at symptomatic changes and do not target the core pathology in the brain of autism. Cell therapy has recently emerged as a promising treatment modality for autism. However, the effects of cell therapy need to be monitored by objective imaging. In this study, we present the case of a 6 year old boy with autism treated with intrathecal administration of autologous bone marrow mononuclear cells and monitored with Positron Emission Tomography - Computer Tomography scan. On regular follow up at 3 and 6 months, significant social, behavioral and communication improvements were observed. On outcome measures, the Indian Scale for Assessment of Autism score pre - intervention improved from 113 to 97, Functional Independence Measure improved significantly from 42 to 50 and Childhood Autism Rating Scale improved from 42.5 to 35.5. The severity of illness on Clinical Global Impression scale showed a change from a score of 5 (markedly ill) to 4 (moderately ill). Global improvement graded on the CGI scale was 2 (much improved). The efficacy index on Childhood Autism Rating Scale showed moderate therapeutic effect (score 5). Interestingly, Positron Emission Tomography - Computer Tomography comparisons at 6 months revealed improved metabolism of the previously hypometabolic areas of the brain which correlated well with clinical improvements. No adverse events were reported.


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