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ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
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Review Article

Pharmacogenetics: Would it be a Reason for the Lack of Potency and Intrinsic Toxicity of Several Natural Medicines?

Tibebe Z. Woldemariam*, Nancy Wageih Hanna and David Pearson

Pharmaceutical and Biomedical Sciences, California Northstate University College of Pharmacy, 10811 International Drive, Rancho Cordova, CA 95670, USA

*Corresponding Author:
Tibebe Z. Woldemariam
Pharmaceutical and Biomedical Sciences
California Northstate University College of Pharmacy
10811 International Drive, Rancho Cordova, CA 95670, USA
E-mail: [email protected]

Received Date: July 13, 2012; Accepted Date: August 08, 2012; Published Date: August 10, 2012

Citation: Woldemariam TZ, Hanna NW, Pearson D (2012) Pharmacogenetics: Would it be a Reason for the Lack of Potency and Intrinsic Toxicity of Several Natural Medicines? J Proteomics Bioinform 5: 190-195. doi: 10.4172/jpb.1000234

Copyright: © 2012 Woldemariam TZ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The use of natural products in drug discovery screening has declined because of the apparent disadvantages of natural products including large-scale procurement of sufficient source material for bulk production, the lack of potency and intrinsic toxicity of many natural products. However, very little effort has been made looking at the influence of pharmacogenetics in the efficacy and toxicity of natural medicines. Pharmacogenomics may possibly enhance drug discovery and development from natural sources by identifying drug targets and enhancing the subpopulation-specific drug development.

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