alexa Pharmacogenomics of Oral P2Y12 Receptor Blockers
ISSN: 2153-0645

Journal of Pharmacogenomics & Pharmacoproteomics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Pharmacogenomics of Oral P2Y12 Receptor Blockers

Talha AR Meeran 1 , Nachiket Apte1 , Eli I Lev1,2, Martin G Gesheff 1 , Udaya S Tantry1 * and Paul A Gurbel1

1Sinai Center for Thrombosis Research, Sinai Hospital of Baltimore, West Belvedere, Avenue, Baltimore, MD, USA

2Rabin Medical Center, Cardiology Department, Petah-Tikava, Israel, and the Tel-Aviv University, Israel

*Corresponding Author:
Udaya S Tantry, PhD
Sinai Center for Thrombosis Research
Cardiac Catheterization Laboratory 2401
W. Belvedere Ave, Baltimore
MD 21215, USA
Fax: 410-601-9601
Phone: 410-601-9600
E-mail: [email protected]

Received date: July 26, 2013; Accepted date: October 21, 2013; Published date: October 30, 2013

Citation: Meeran TAR, Apte N, Lev EI, Gesheff MG, Tantry US, et al. (2013) Pharmacogenomics of Oral P2Y12 Receptor Blockers. J Pharmacogenomics Pharmacoproteomics 4:119. doi: 10.4172/2153-0645.1000119

Copyright: © 2013 Meeran TAR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided theoriginal author and source are credited.

Abstract

Dual antiplatelet therapy of aspirin and a P2Y12 receptor antagonist is the cornerstone of therapy for patients. Thienopyridines (ticlopidine, clopidogrel and prasugrel) are prodrugs that need cytochrome–mediated conversion to active metabolites to block P2Y12 receptors and subsequent ADP-induced platelet aggregation. Clopidogrel response variability has been attributed to a variable generation of its active metabolite which is in turn influenced by single nucleotide polymorphisms of genes associated with intestinal absorption protein, ABCB1 and hepatic cytochrome isoenzymes particularly CYP2C19. Moreover, presence of loss-of-function allele of CYP2C19 gene has been associated with poor active metabolite generation, poor antiplatelet response and increased risk for cardiovascular event occurrences particularly stent thrombosis in patients treated with clopidogrel. Recent studies suggest that genetic variations in CYP2C19 and CYP2B6 may affect response to the drug; however its clinical significance is unknown at this time. Although, ticagrelor (a cyclopentyl-triazolo-pyrimidine), is a prodrug, it is metabolized by CYP3A4 and its active metabolite is as potent as parent drug. To date there are no reports of significant influence of genotype variations on ticagrelor metabolism, its antiplatelet response or clinical outcome. The optimal strategy to overcome the influence of LoF carriage in patients treated with clopidogrel is probably to switch therapy to either prasugrel or ticagrelor, although large-scale studies assessing this approach have not been performed.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords