Pharmacokinetics of Diminazene Aceturate in Buffalo Calves
- *Corresponding Author:
- Birendra Kumar Roy,
University Professor& Chairman
Dept. of Pharmacology and Toxicology
Faculty of Veterinary Science & A.H
Birsa Agricultural University
Ranchi - 834006, India,
Tel: 91-651- 2450759
Received Date: February 03, 2010; Accepted Date: March 12, 2010; Published March 12, 2010
Citation: Pandey HK, Singh KK, Roy BK, Kumari S (2010) Pharmacokinetics of Diminazene Aceturate in Buffalo Calves. J Bioanal Biomed 2:013-016. doi:10.4172/1948-593X.1000015
Copyright: © 2010 Pandey HK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The pharmacokinetic study of diminazene aceturate (DMZ) was carried out in two separate groups of 4 e ach clinically healthy female Murrah buffalo calves aft er single dose i.v. (8 mg/kg) and i.m. (16 mg/kg) administrat ion. The mean free peak serum concentration of DMZ (CS max ) after i.v. (26.28±0.67μ g/ml) and i.m. (8.41±2.43 μ g/ml) a dmin- istrations were obtained at t max of 5 and 30 min respectively. The DMZ serum concentrations time data were best fi tted to the two compartment open model. The calculated s erum half life (t ½ β ) values of DMZ were 15.099±2.504 and 14.225±2.682 h after i.v. and i.m. administration r espec- tively. The mean values of total body clearance rat e of DMZ (ClB) after i.m. (3.785±1.119 ml/kg/min) was signif icantly higher (P<0.05) as compared with the i.v. (0.537±0. 063 ml/kg/min). DMZ was highly bound (77.14 to 94.40%) to buffalo calf plasma protein and its penetration int o erythro- cytes increased with increasing concentrations in b lood (7.60 to 33.00μ g/ml). Based on pharmacokinetic profiles, the satisfactory dosage regimens of diminazene aceturat e in buffalo calves were derived (2 mg/kg, i.v. and 12mg /kg, i.m). In case of emergent disease conditions to ens ure high DMZ serum concentrations, i.v. route may be preferr ed over i.m. route.