alexa Pharmacokinetics of Purified Paeonol and Paeonol in Moutan Cortex Decoction and Rhubarbmoutan Decoction | OMICS International | Abstract
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Research Article

Pharmacokinetics of Purified Paeonol and Paeonol in Moutan Cortex Decoction and Rhubarbmoutan Decoction

Wu Jing1*, Zhang Rui2, Yuan Gui-yan2 and Guo Rui-chen2*

1Pharmacy Department, The Second Hospital of Shandong University, Jinan 250033, China

2Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan 250012, China

*Corresponding Authors:
Dr. WU Jing
Postgraduate, Pharmacist Majoring in the Clinical Pharmacology, China
Tel: 15954907800;
E-mail: [email protected]
 
Dr. GUO Rui-chen
Correspondence Author, Professor Tutor of Doctor
Majoring in Clinical Pharmacology and Pharmacokinetics, China
Tel: 0531-82169636
E-mail: [email protected]

Received: June 07, 2011; Accepted: June 22, 2011; Published: June 24, 2011

Citation: Jing W, Rui Z, Gui-yan Y, Rui-chen G (2011) Pharmacokinetics of Purified Paeonol and Paeonol in Moutan Cortex Decoction and Rhubarbmoutan Decoction. Pharm Anal Acta 2:124. doi:10.4172/2153-2435.1000124

Copyright: © 2011 Jing W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

180 KM male mice of 22~28g body weight were divided into three groups randomly and purified paeonol, Moutan Cortex decoction and Rhubarbmoutan decoction were orally administered at equivalent doses of 10 mg·kg -1 paeonol. A sensitive HPLC method was established and evaluated for determining the concentrations of paeonol in mice plasma. The main pharmacokinetic parameters of paeonol were as follows: t 1/2 , (13.15± 2.48) min, (15.04±4.40) min and (21.83±6.21) min, T max , 15 min, 15 min and 10 min, C max , (69.41±4.50) ng·mL -1 , (82.90±6.10) ng·mL -1 and (123.32±5.55) ng·mL -1 , AUC 0-t , (1243.42±109.75)ng·min·mL -1 , (1412.74±97.72) ng·min·mL -1 and (2162.20±105.10) ng·min·mL -1 , AUC 0-∞ , (2192.46 ±472.18) ng·min·mL -1 ,( 2659.57±1590.70) ng·min·mL -1 and (3423.36 ±465.40) ng·min·mL -1 ,respectively. All the results indicate that disposition in mice were affected by other components in Chinese herbs and in recipe.

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