alexa Pharmacologic Management of Non-Alcoholic Fatty Liver Disease
ISSN: 2167-1052

Advances in Pharmacoepidemiology and Drug Safety
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Review Article

Pharmacologic Management of Non-Alcoholic Fatty Liver Disease

George Boon-Bee Goh*, Srinivasan Dasarathy and Arthur McCullough
Departments of Gastroenterology, Cleveland Clinic Foundation 9500 Euclid Avenue/ A30 Cleveland, OH 44195, USA
*Corresponding Author : Arthur McCullough, M.D
Department of Gastroenterology
Cleveland Clinic Foundation 9500 Euclid Avenue/A30 Cleveland
OH 44195, USA
Tel: 1-216-444-6521
Fax: 1-216-445-3889
E-mail: [email protected]
Received June 11, 2014; Accepted June 28, 2014; Published June 30, 2014
Citation: Goh GBB, Dasarathy S, McCullough A (2014) Pharmacologic Management of Non-Alcoholic Fatty Liver Disease. Adv Pharmacoepidemiol Drug Saf 3:157. doi:10.4172/2167-1052.1000157
Copyright: © 2014 Goh GBB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a common complex chronic liver disease that encompasses a spectrum of disease from simple steatosis to non-alcoholic steatohepatitis (NASH). NASH has the potential to progress to advanced fibrosis and cirrhosis and is associated with increased morbidity and mortality. Currently, there are no definitive universally accepted treatment options available for NASH. Most pharmacological agents that have been investigated are limited by inconsistent efficacy or side effects. We reviewed the current literature on the principle drugs that have been tested for NAFLD in the adult population, with special emphasis on clinical data and safety profiles. Methods: A comprehensive PUBMED/MEDLINE search was conducted to identify principal therapeutic intervention studies for NAFLD, from which a summary of the studies were formulated in this review. Results: A variety of studies, including retrospective, open-label and randomised controlled trials were reviewed in terms of clinical efficacy and side effect profiles. In addition to the most commonly studied therapeutic agents (insulin sensitizers, vitamin E, pentoxifylline, UDCA, PUFA, statins and ezetimibe), emerging pharmacologic agents showing potential efficacy in NAFLD were also explored. Conclusion: Based on risk-benefit profiles, pentoxifylline seems to have the best treatment outcomes currently, with significant improvement in histology while having minimal tolerable side effects. Further clinical research is warranted to understand and improve our repertoire of treatment options, including potential combination therapy, towards this complex disease.

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