alexa Pharmacological Activities and Progress in Structure Modification of Salidroside | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Pharmacological Activities and Progress in Structure Modification of Salidroside

Xuewei Luo, Na Bao, Li Chen* and Jianbo Sun*

Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tongjia Lane, Nanjing, 210009, China.

*Corresponding Authors:
H Li Chen
Department of Natural Medicinal Chemistry
China Pharmaceutical University
24 Tongjia lane, Nanjing 210009, China
Tel: 86- 25-83271415
E-mail: [email protected]
Jianbo Sun
Department of Natural Medicinal Chemistry
China Pharmaceutical University
24 Tongjia lane, Nanjing 210009, China
Tel/Fax: 862583271415
Email: [email protected]

Received Date: March 04, 2017 Accepted Date: March 15, 2017 Published Date: March 21, 2017

Citation: Luo X, Bao N, Chen L, Sun J (2017) Pharmacological Activities and Progress in Structure Modification of Salidroside. Med Chem (Los Angeles) 7: 818-823. doi: 10.4172/2161-0444.1000434

Copyright: © 2017 Luo X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal (TCM) plant, and has displayed a broad spectrum of pharmacological properties, such as resisting anoxia, antiradiation and antifatigue. In addition, it has low toxicity as traditional Chinese medicinal plant. However, the bioavailability of salidroside is low because of its instability for hydrolase. Lots of researchers modified the structure of salidroside to enhance its bioactivity. This paper summarizes the structure modification and activities study of salidroside in recent ten years, and preliminary discuss the structure-activity relationship of salidroside analogues, which hope to provide new ideas of modification in future.

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