alexa Pharmacological Options Beyond Proton Pump Inhibitors i
ISSN: 2329-6631

Journal of Developing Drugs
Open Access

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Review Article

Pharmacological Options Beyond Proton Pump Inhibitors in Children with Gastroesophageal Reflux Disease

Armano C, Fumagalli LA, Ripepi A, Moretti A, Macchi F, Scolari A and Salvatore S*

Pediatric Department, Ospedale “F. Del Ponte”, Università dell’Insubria, Varese, Italy

*Corresponding Author:
Salvatore S
Pediatric Department, Ospedale “F. Del Ponte”
Università dell’Insubria, Varese, Italy
Tel: 0039-0-332 299247
E-mail: [email protected]

Received date: August 29, 2016; Accepted date: October 10, 2016; Published date: October 18, 2016

Citation: Armano C, Fumagalli LA, Ripepi A, Moretti A, Macchi F, et al. (2016) Pharmacological Options Beyond Proton Pump Inhibitors in Children with Gastroesophageal Reflux Disease. J Dev Drugs 5:161. doi:10.4172/2329-6631.1000161

Copyright: © 2016 Armano C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Pharmacological treatment of gastroesophageal reflux (GER) disease is mostly based on acid control. However, different molecules have been proposed both for patients with persisting symptoms and to limit adverse effects of proton pump inhibitors (PPI). This paper focuses on other acid inhibitors, alginate, prokinetics, drug acting on lower esophageal sphincter and esophageal hypersensitivity. Mechanism of action, indications, efficacy, limits and recent advances are reported. Pediatric data and possible adverse effects are also considered.

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