Pharmacological Options Beyond Proton Pump Inhibitors in Children with Gastroesophageal Reflux DiseaseArmano C, Fumagalli LA, Ripepi A, Moretti A, Macchi F, Scolari A and Salvatore S*
Pediatric Department, Ospedale âF. Del Ponteâ, UniversitÃ dellâInsubria, Varese, Italy
- *Corresponding Author:
- Salvatore S
Pediatric Department, Ospedale “F. Del Ponte”
Università dell’Insubria, Varese, Italy
Tel: 0039-0-332 299247
E-mail: [email protected]
Received date: August 29, 2016; Accepted date: October 10, 2016; Published date: October 18, 2016
Citation: Armano C, Fumagalli LA, Ripepi A, Moretti A, Macchi F, et al. (2016) Pharmacological Options Beyond Proton Pump Inhibitors in Children with Gastroesophageal Reflux Disease. J Dev Drugs 5:161. doi:10.4172/2329-6631.1000161
Copyright: © 2016 Armano C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Pharmacological treatment of gastroesophageal reflux (GER) disease is mostly based on acid control. However, different molecules have been proposed both for patients with persisting symptoms and to limit adverse effects of proton pump inhibitors (PPI). This paper focuses on other acid inhibitors, alginate, prokinetics, drug acting on lower esophageal sphincter and esophageal hypersensitivity. Mechanism of action, indications, efficacy, limits and recent advances are reported. Pediatric data and possible adverse effects are also considered.