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Has Anyone so far Bridged the Gap between microRNA, Botanicals and Oropharyngeal Squamous Cell Carcinoma? | OMICS International | Abstract
ISSN: 2327-5162

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Opinion Article

Has Anyone so far Bridged the Gap between microRNA, Botanicals and Oropharyngeal Squamous Cell Carcinoma?

Mohammed E Grawish1*, Mathias Wagner2, Benjamin Vicinus3, Michael J Jack4, Tereza Richards5, Ahmed Ragheb Zaher1 and Chen Xi6

1Department of Oral Biology, Mansoura University, Egypt

2Department of Pathology, Saar State University, Homburg Campus, Homburg Saar, Germany

3Department of General, Visceral, Vascular and Paediatric Surgery, Saar State University, Homburg Campus, Homburg Saar, Germany

4Competence Centre for Complementary Medicine and Naturopathy, Technical University Munich, Munich, Germany

5Medical Library, University of the West Indies, Mona Campus, Kingston, Jamaica, W.I.

6Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Hom, Kowloon, Hong Kong

*Corresponding Author:
Grawish ME
Georgetown University School of Medicine
Tel: 202 877-1964
E-mail: [email protected]

Received date May 06, 2014; Accepted date July 11, 2014; Published date July 13, 2014

Citation: Grawish ME, Wagner M, Vicinus B, Jack MJ, Richards T, et al. (2014) Has Anyone so far Bridged the Gap between microRNA, Botanicals and Oropharyngeal Squamous Cell Carcinoma?. Altern Integr Med 3:163. doi:10.4172/2327-5162.1000163

Copyright: © 2014 Grawish ME et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background/Context: Current debate concerning properties of oropharyngeal squamous cell carcinoma (OSCC) is nothing new. More recent information can be found on functional aspects of microRNA (miRNA) in botanicals and mammals, suggesting that the aging process and cancer development are regulated by these molecules. Interestingly, some dietary supplements (especially botanicals) have been reported to have cancer chemopreventive and/or anti-cancer properties and are common ingredients in so-called "anti-aging" creams. Objective: The present study was therefore conducted to determine the state-of-the-art on botanicals, OSCC, and their relationship to miRNA. Methods/Design: PubMed and Google Scholar were interrogated for articles published in English between January 1, 2000 and December 31, 2010 that discuss botanicals and which could possibly be used in treating OSCC. Additional searches in Google, Google Scholar, PubMed and KoreaMed were conducted to detect possible associations between miRNAs and the aforementioned items. Results: The current body of literature suggests that botanicals might deliver some of their properties via miRNAs. No report was found however that makes a direct connection to OSCC. It therefore has not been determined whether there is an association between botanicals, OSCC, and miRNA molecules that could possibly have "anti-aging" as well as cancer chemopreventive and/or anti-cancer properties. Conclusions: Systematic studies are needed to determine whether it is miRNA that could dispense possible therapeutic properties of botanicals on OSCC  


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