alexa pH-controlled Release System for Curcumin based on Func
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

Khaled EA AbouAitah1, Farghali AA2*, Anna Swiderska-Sroda3, Witold Lojkowski3*, Abdel-Fattah M Razin1 and Khedr MH2

1Department of Medicinal and Aromatic Plants Research, Pharmaceutical and Drug Industries Research Division, National Research Centre (NRC), Dokki, Giza, Egypt.

2Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt.

3Laboratory of Nanostructures for Photonic and Nanomedicine Institute of High Pressure Physics, Polish Academy of Sciences, Warsaw, Poland

*Corresponding Author:
Lojkowski W
Laboratory of Nanostructures for Photonic and Nanomedicine
Institute of High Pressure Physics
Polish Academy of Sciences
Warsaw, Poland
Tel: 48228880429
E-mail: [email protected]

Farghali AA
Materials Science and Nanotechnology Department
Faculty of Postgraduate Studies for Advanced Sciences
Beni-Suef University, Beni-Suef, Egypt
Tel: 48228880429
E-mail: [email protected]

Received Date: December 10, 2015; Accepted Date: February 01, 2016; Published Date: February 10, 2016

Citation: AbouAitah KEA, Farghali AA, Swiderska-Sroda A, Lojkowski W, Razin AMF, et al. (2016) pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles. J Nanomed Nanotechnol 7:351. doi:10.4172/2157-7439.1000351

Copyright: © 2016 AbouAitah KEA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Mesoporous silica materials are promising drug delivery systems, especially in case of poorly water-soluble drugs. Curcumin (Cur) has proven effective for several pharmacological activities including anti-inflammatory, antioxidant, antimicropeal, hepatoprotective, and anticancer activities. In the present work two types of mesoporous silica nanoparticles were evaluated as a Cur carrier for controlled release of this anticancer natural pro-drug: MCM-41 (Two Dimensional) and KCC-1 (Three Dimensional), both functionalized with aminopropyl groups. KCC-NH2 and MCM-NH2 contained a similar amount of Cur (24.5% and 23.9%, respectively). In vitro experiments have shown that both materials effectively release Cur and the cumulative release was enhanced for low acidity (pH=2.5). At low acidic pH (2.5), the KCC-1 sample released higher amount (up to 19%) of curcumin compared to MCM-41 (14%). Thus it is possible to achieve controlled, long-term and effective pH-stimulated release of curcumin from aminefunctionalized mesoporous silica nanoparticles. This finding opens the way for their application for controlled curcumin delivery in cancer disease because of the acidic tumor environment, increase its stability and lead to an increase of the Cur bioavailability. Moreover, the KCC-1 three dimensional mesoporous silica seems to be a more promising nanocarrier compared to the commonly used MCM-41 material.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords