pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica NanoparticlesKhaled EA AbouAitah1, Farghali AA2*, Anna Swiderska-Sroda3, Witold Lojkowski3*, Abdel-Fattah M Razin1 and Khedr MH2
- *Corresponding Author:
- Lojkowski W
Laboratory of Nanostructures for Photonic and Nanomedicine
Institute of High Pressure Physics
Polish Academy of Sciences
E-mail: [email protected]
Materials Science and Nanotechnology Department
Faculty of Postgraduate Studies for Advanced Sciences
Beni-Suef University, Beni-Suef, Egypt
E-mail: [email protected]
Received Date: December 10, 2015; Accepted Date: February 01, 2016; Published Date: February 10, 2016
Citation: AbouAitah KEA, Farghali AA, Swiderska-Sroda A, Lojkowski W, Razin AMF, et al. (2016) pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles. J Nanomed Nanotechnol 7:351. doi:10.4172/2157-7439.1000351
Copyright: © 2016 AbouAitah KEA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mesoporous silica materials are promising drug delivery systems, especially in case of poorly water-soluble drugs. Curcumin (Cur) has proven effective for several pharmacological activities including anti-inflammatory, antioxidant, antimicropeal, hepatoprotective, and anticancer activities. In the present work two types of mesoporous silica nanoparticles were evaluated as a Cur carrier for controlled release of this anticancer natural pro-drug: MCM-41 (Two Dimensional) and KCC-1 (Three Dimensional), both functionalized with aminopropyl groups. KCC-NH2 and MCM-NH2 contained a similar amount of Cur (24.5% and 23.9%, respectively). In vitro experiments have shown that both materials effectively release Cur and the cumulative release was enhanced for low acidity (pH=2.5). At low acidic pH (2.5), the KCC-1 sample released higher amount (up to 19%) of curcumin compared to MCM-41 (14%). Thus it is possible to achieve controlled, long-term and effective pH-stimulated release of curcumin from aminefunctionalized mesoporous silica nanoparticles. This finding opens the way for their application for controlled curcumin delivery in cancer disease because of the acidic tumor environment, increase its stability and lead to an increase of the Cur bioavailability. Moreover, the KCC-1 three dimensional mesoporous silica seems to be a more promising nanocarrier compared to the commonly used MCM-41 material.