alexa Phospholipase A2: A Potential Therapeutic Target in Inflammation and Cancer (In silico, In vitro, In vivo and Clinical Approach) | OMICS International
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Review Article

Phospholipase A2: A Potential Therapeutic Target in Inflammation and Cancer (In silico, In vitro, In vivo and Clinical Approach)

Nagendra sastry Yarla1*, Koduri Satyakumar1, Duppalapudi Srinivasu1, Kaladhar DSVGK1, Gjumrakch Aliev2,3, Gangappa Dharmapuri4,5, Goutham Raju SP Swathi Putta6, Srinivas Jagarlapoodi7 Vemareddy Bheeram1, Surya Prabha Sadu6 and Govinda Rao Duddukuri1
1Department of Biochemistry/Bioinformatics, School of Life Sciences, GITAM Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India
2GALLY” International Biomedical Research Consulting LLC, San Antonio, TX 78229, USA
3School of Health Sciences and Healthcare Administration, University of Atlanta, E. Johns Crossing, #175, Johns Creek, GA, USA
4Department of Biotechnology, Sri Krishnadevaraya University, Anantapur 515003, A.P., India
5Department of Animal Biology, University of Hyderabad, Hyderabad 500046, Telangana state, India
6AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P., India
7Department of Biotechnology, CMR college of engineeringad technology, Kandlakoya, Hyderabad, Telangana state, India
Corresponding Author : Nagendra Sastry Yarla
Department of Biochemistry/Bioinformatics
School of Life Sciences, GITAM Institute of Science
GITAM University, Visakhapatnam, A.P., India
Tel: +91-9701608894
E-mail: [email protected]
Received September 08, 2014; Accepted July 14, 2015; Published July 17, 2015
Citation: Yarla NS, Satyakumar K, Srinivasu D, Kaladhar DSVGK, Aliev G, et al. (2015) Phospholipase A2: A Potential Therapeutic Target in Inflammation and Cancer (In silico, In vitro, In vivo and Clinical Approach). J Cancer Sci Ther 7:249-252. doi:10.4172/1948-5956.1000357
Copyright: © 2015 Yarla NS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Phospholipase A2 (PLA2) (EC 3.1.1.4) is the initial enzyme of arachidonic acid cascade, has key role in inflammation and cancer. Hence, PLA2 inhibitors have wide medicinal importance. This short review focused on PLA2 structure, function and role in inflammation and cancer. Further we tried to collect PLA2 inhibitors from the previous literature and explained the possibility of their utility as anti-inflammatory and anticancer agents.

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