alexa Phosphoproteomic Analysis of Pancreatic Ductal Adenocar
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

Phosphoproteomic Analysis of Pancreatic Ductal Adenocarcinoma Cells Reveals Differential Phosphorylation of Cell Adhesion, Cell Junction and Structural Proteins

Weidong Zhou1*, Michela Capello2,3, Claudia Fredolini1,2,3, Leda Racanicchi4, Lorenzo Piemonti4, Lance A. Liotta1, Francesco Novelli2,3 and Emanuel F. Petricoin1

1Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110, USA

2Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, Turin 10126, Italy

3Department of Medicine and Experimental Oncology, University of Turin, Turin 10125, Italy

4Diabetes Research Institute, San Raffaele Scientific Institute, Milano 20132, Italy

*Corresponding Author:
Dr. Weidong Zhou
Center for Applied Proteomics and Molecular Medicine
George Mason University, 10900 University Blvd, MS 1A9
Manassas, VA 20110, USA
Tel: 703-993-9492
Fax: 703-993-4288
E-mail: [email protected]

Received Date: August 04, 2011; Accepted Date: September 13, 2011; Published Date: September 21, 2011

Citation: Zhou W, Capello M, Fredolini C, Racanicchi L, Piemonti L, et al. (2011) Phosphoproteomic Analysis of Pancreatic Ductal Adenocarcinoma Cells Reveals Differential Phosphorylation of Cell Adhesion, Cell Junction and Structural Proteins. J Proteomics Bioinform 4:170-178. doi:10.4172/jpb.1000186

Copyright: © 2011 Zhou W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In this present work, we characterized the phosphoproteomes of pancreatic ductal adenocarcinoma (PDAC) cells and normal pancreatic duct cells by mass spectrometry using LTQ-Orbitrap. We identified more than 700 phosphoproteins from each sample, and revealed differential phosphorylation of many proteins involved in cell adhesion, cell junction, and cytoskeleton. Since post-translational phosphorylation is a common and important mechanism of acute and reversible regulation of protein function in mammalian cells, an understanding of differential phosphorylation of these proteins and resulting signal transduction changes in PDAC will help in comprehending the complex dynamics of tumor invasion and metastasis in pancreatic cancer.


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