- *Corresponding Author:
- Rupesh Raina
Fellow at Rainbow Babies and Children Hospital
Case Western Reserve
Cleveland, OH, USA
E-mail: [email protected] uhhospitals.org
Received Date: April 12, 2012; Accepted Date: July 20, 2012; Published Date: July 25, 2012
Citation: Raina R, Garg G, Sethi SK, Schreiber MJ, Simon JF, et al.(2012) Phosphorus Metabolism. J Nephrol Therapeutic S3:008. doi:10.4172/2161-0959.S3-008
Copyright: © 2012 Raina R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Phosphorus plays a pivotal role in various biological processes. Therefore, a deeper understanding of Phosphorus Homeostasis is essential for management and treatment of conditions causing an imbalance in phosphate metabolism. The widely understood parathyroid hormone (PTH) and vitamin D axis that governs this phosphate homeostasis has been critiqued for its inability to explain a few rare genetic and acquired conditions associated with phosphate imbalance. Such conditions are characterized by normal PTH and activated vitamin D hormone. For example, Tumor Induced osteomalacia, Autosomal Dominant hypophosphatemic rickets, and X-linked hypophosphatemic rickets.
Recent studies of such conditions have led to the discovery of additional factors that play an important role in phosphorus homeostasis. These phosphaturetic factors, called “Phosphatonins” include Fibroblast Growth Factor 23 (FGF-23), Fibroblast Growth Factor 7 (FGF7), Frizzled related protein 4 (FRP4), and matrix extracellular phosphoglycoprotein (MEPE).Out of these phosphatonins, FGF-23 has been extensively studied. This article aims to summarize the importance of phosphatonins in hypo- and hyperphosphatemic conditions along with the physiological and clinical importance of such factors. Furthermore, we tried to summarize current knowledge regarding diagnosis and management of such conditions.