Photo-bactericidal Properties of Hydroxyapatite Implant Surface Coating
- Corresponding Author:
- Sharova AS
National Research Nuclear
University, MEPhI, Russia, Moscow
Tel: +7 495 788-56-99
E-mail: [email protected]
Received date: July 19, 2016; Accepted date: July 27, 2016; Published date: August 05, 2016
Citation: Maklygina YS, Sharova AS, Kundu B, Balla VK, Steiner R, et al. (2016) Photo-bactericidal Properties of Hydroxyapatite Implant Surface Coating. Bioceram Dev Appl 6:094. doi: 10.4172/2090-5025.1000094
Copyright: © 2016 Maklygina YS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Implant-associated infection is a common postoperative complication and remains a serious problem in the surgery. This work describes the development of hydroxyapatite implants with photo-bactericidal properties by the surface coating. The unique coating as crystalline nanoparticles of IR photosensitizers of implant was investigated using infrared spectroscopy. It has been proved that by the interaction of nanoparticles covering implant with the polar solvent, which simulates the interaction of the implant with the biocomponents in vivo (fast proliferating and with immune-competent cells), IR photosensitizers nanoparticles change the spectroscopic properties, becoming fluorescent and phototoxic. Thus, the developed coating based on crystalline IR photosensitizer nanoparticles with studied specific properties should have antibacterial, anti-inflammatory effect by the photodynamic treatment in the near implant area. This research opens the prospect of such technology application in order to provide the local inflammatory and autoimmune reactions prevention in the area of implantation that will improve implant antimicrobial effects and reduce potential long-term cytotoxicity. The results of the study suggest a promising this technology in order to create implants with photo-bactericidal properties.