alexa Phylogenetic Analyses of the Loops in Elongation Factors EF1A: Stronger Support for the Grouping of Animal and Fungi | OMICS International | Abstract
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
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Research Article

Phylogenetic Analyses of the Loops in Elongation Factors EF1A: Stronger Support for the Grouping of Animal and Fungi

Oxana V. Galzitskaya1, Eugeniya I. Deryusheva3 and Igor N. Serdyuk1,2*

1Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russian Federation

2Joint Institute for Nuclear Research, Dubna, Moscow Region, 141980, Russian Federation

3Tula State University, 300600, Tula, Russian Federation

Oxana V. Galzitskaya: [email protected], Eugeniya I. Deryusheva: [email protected]

*Corresponding Author:
Dr. I. N. Serdyuk
Institute of Protein Research
Russian Academy of Sciences
Pushchino, Moscow Region, 142290
Phone : 0-007-496-7732927,
Fax     : 0-007-495-632-78-71,
Email  : [email protected]

Received Date: December 04, 2008; Accepted Date: December 23, 2008; Published Date: December 26, 2008

Citation: Oxana VG, Eugeniya ID, Igor NS (2008) Phylogenetic Analyses of the Loops in Elongation Factors EF1A: Stronger Support for the Grouping of Animal and Fungi. J Comput Sci Syst Biol 1:073-080. doi: 10.4172/jcsb.1000006

Copyright: © 2008 Oxana VG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Discerning how different major groups of organisms are related to each other and tracing their evolution from the common ancestor remains controversial and unsolved. In recent years, much new information based on a large number of gene and protein sequences has become available. So far phylogenetic analysis can be carried out based on either nucleic acid or protein sequences. However it was become evident that both approaches have a many serious limitations and pitfalls. Our novel findings follows from analysis of loops in elongation factors EF1A using novel informative characteristic which was called “loops” method. The method is based on the ability of amino acid sequences form loops in protein structure. The specificity of a criterion for grouping organisms is distinctly evident from the analysis of the loops using EF1A for three kingdoms of life. Each kingdom displayed variations in the number of loops and their location within the three EF1À domains and can be consider as imprint of molecular evolution. Stronger support that animals and fungi are sibling kingdoms was found.

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