alexa Phylogenetic Analysis of ASPM, a Major Contributor Gene of Microcephaly
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Phylogenetic Analysis of ASPM, a Major Contributor Gene of Microcephaly

Sobiah Rauf and Asif Mir*

Bioinformatics & Biotechnology, DES, International Islamic University, Islamabad, Pakistan

*Corresponding Author:
Asif Mir
Bioinformatics & Biotechnology, DES
International Islamic University, Islamabad, Pakistan
E-mail: [email protected]

Received Date: August 22, 2012; Accepted Date: September 01, 2012; Published Date: September 03, 2012

Citation: Rauf S, Mir A (2012) Phylogenetic Analysis of ASPM, a Major Contributor Gene of Microcephaly. J Proteomics Bioinform 5: 252-255. doi: 10.4172/jpb.1000245

Copyright: © 2012 Rauf S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

ASPM gene at MCPH5 locus is considered a major causative gene of autosomal recessive primary microcephaly (MCPH), which is a rare neurodevelopemental disorder that affects head and brain size. Mutations in this gene have contribution of more than 50% in causing MCPH for which seven loci (MCPH1 to MCPH7) have been discovered so far. The current study includes bioinformatics analysis of ASPM gene at MCPH5 locus. Bioinformatics analysis includes syntenic relationship of ASPM and its phylogenetic studies with reference to various selected orthologs. These studies have revealed information about conservation of genes among different ortholog species and their evolutionary relationship.

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