Phylogenetic Analysis of Coxsackie B Viruses Reveals Genomic Plasticity and Adaptation as Studied by Codon Usage Patterns
- *Corresponding Author:
- Juan Cristina
Laboratorio de Virología Molecular
Centro de Investigaciones Nucleares
Facultad de Ciencias, Uruguay
Tel: +598 2525 09 01
Fax: +598 2525 08 95
E-mail: [email protected]
Received Date: February 06, 2012; Accepted Date: March 07, 2012; Published Date: March 09, 2012
Citation: Recarey R, Moratorio G, Colina R, Cappetta M, Uriarte R, et al. (2012) Phylogenetic Analysis of Coxsackie B Viruses Reveals Genomic Plasticity and Adaptation as Studied by Codon Usage Patterns. J Medical Microbiol Diagnosis S4:001. doi: 10.4172/2161-0703.S4-001
Copyright: © 2012 Recarey R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Coxsackie B viruses (CVB) are associated with serious illnesses in humans. In this study, the patterns of synonymous codon usage in CVB have been studied through multivariate statistical methods. Effective number of codons (ENC) indicates that the overall extent of codon usage bias in CVB is not significant. The relative dinucleotide abundances suggest that codon usage bias in CVB genomes is influenced by underlying biases of dinucleotide frequencies. The distribution of CVB ORFs along the plane defined by the first two axes of correspondence analysis (COA) showed that different genotypes, as well as strains known to infect different cell types, are located at different places in the plane suggesting that CVB codon usage is reflecting an evolutionary process. The results of these studies suggest that CVB genomic biases are the result of co-evolution of translation adaptation to different cell environments and probably the need to escape anti-viral cell defenses.