Phylogenetic Analysis of Genetic Diversity of Hemolysins in Leptospira
- *Corresponding Author:
- Tejpreet Chadha
Department of Biological Sciences
Texas Tech University
BOX 43131, Lubbock, TX 79409, USA
E-mail: [email protected]
Received Date: May 16, 2012; Accepted Date: June 28, 2012; Published Date: July 05, 2012
Citation: Chadha T, Alexandre Trindade A (2012) Phylogenetic Analysis of Genetic Diversity of Hemolysins in Leptospira. J Proteomics Bioinform 5: 152-154. doi: 10.4172/jpb.1000228
Copyright: © 2012 Chadha T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Leptospirosis is a zoonotic disease distributed worldwide. It has now been identified as one of the emerging infectious diseases. The genomic sequences of Leptospira species have helped to identify the genetic diversity of hemolysins among different pathogenic and saprophytic Leptospira species. The phylogenetic analysis reveals that hemolysin SphH, a pore-forming protein on various mammalian cells in pathogenic Leptospira, does not show significant similarity to hemolysins in saprophytic Leptospira biflexa. The Leptospira interrogans hemolysin gene also does not show significant similarity to L. biflexa and Leptospira borgpetersenii. The genetic diversity among hemolysin genes in Leptospira suggests that the gain of more hemolysin genes during the course of their evolution may have contributed to their virulence.