alexa Phylogenetic Characterization and Threading Based-Epito
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

Phylogenetic Characterization and Threading Based-Epitope Mapping of Leptospiral Outer Membrane Lipoprotein Lipl41

Angela Asir Ramasamy Victor2, Sunil Abraham1, Manimaran Nellai Chinniah1, Madanan Gopalakrishnan Madathiparambil3 and Jebasingh Tennyson1*

1School of Biological Sciences, Madurai Kamaraj University, Madurai-625021, Tamil Nadu, India

2St. Michael college of Engineering and Technology, St. Santhiagappar Nagar, Kalayarkoil-630 551, Sivagangai district, Tamil Nadu, India

3Regional Medical Research Centre (ICMR), Post Bag No-13, Port Blair-744 101, Andaman and Nicobar Islands, India

*Corresponding Author:
Jebasingh Tennyson
School of Biological Sciences
Madurai Kamaraj University
Madurai-625021, Tamil Nadu, India
Tel: +91-9043568671
Fax: +91-4522459873
E-mail: [email protected]

Received Date: June 05, 2014; Accepted Date: July 21, 2014; Published Date: July 25, 2014

Citation: Victor AAR, Abraham S, Chinniah MN, Gopalakrishnan Madathiparambil M, Tennyson J (2014) Phylogenetic Characterization and Threading Based-Epitope Mapping of Leptospiral Outer Membrane Lipoprotein LipL41. J Proteomics Bioinform 7: 222-231.doi: 10.4172/jpb.1000323

Copyright: © 2014 Victor AAR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Leptospiral outer membrane Lipoprotein LipL41 is one of the key virulence factor expressed during leptospiral infection on mammalian host. Phylogenetic analysis of LipL41 from 87 pathogenic species has shown the comprising lineages of LipL41 with largely varying rates of evolution. The species of L. borgpetersenii are clustered together and form a group with highest bootstrap value. Relationships between the species Lai and Copenhageni are resolved by 20 and 8 sequences separately with highest and lowest bootstrap values of 99 and 50, respectively. Molecular model of LipL41 was predicted in Raptor X server to map eight sequential and conformational B cell epitopes of LipL41 in Ellipro server. All these epitopes were found to be conserved among Leptospira and these could be used for the development of vaccine and diagnostic kit to detect Leptospira

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