Phylogenetic Considerations in the Evolutionary Development of Aminoglycoside Resistance Genes in Pathogenic Bacteria
Received Date: Nov 06, 2015 / Accepted Date: Dec 16, 2015 / Published Date: Dec 22, 2015
This study revisits antibiotic resistance as a source of evolutionary development in pathogenic bacteria. By taking a molecular phylogenetic approach to this inquiry, I seek to find homologous correlations in antimicrobial resistance gene families across a broad spectrum of bacteria, as to identify the possible acquisition of those genes through divergent events in evolutionary context. In order to test this, I examine the various degrees of genetic similarity in two antimicrobial resistance genomic datasets, namely aadA1 and aadA2 aminoglycoside resistance genes, among bacteria that occur in a multitude of environments. Moreover, the results from phylogenetic analysis suggests that pathogenic antibiotic resistance for aadA1 and aadA2 aminoglycoside resistance genes may have been acquired through evolutionary events with a common ancestor of a soil-dwelling bacterium.
Keywords: Bacteria; Pathogens; Phylogeny; Molecular phylogenetics; Aminoglycoside resistance genes; Antimicrobial resistance; Multiple sequence alignment; Comparative genomics
Citation: Rodriguez T (2015) Phylogenetic Considerations in the Evolutionary Development of Aminoglycoside Resistance Genes in Pathogenic Bacteria. J Phylogen Evolution Biol 4: 162. Doi: 10.4172/2329-9002.1000162
Copyright: © 2015 Rodriguez T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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