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Hot Immunological Topics in HIV Infection | OMICS International | Abstract
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Review Article

Hot Immunological Topics in HIV Infection

Juan A. Pineda1*, José Alcamí2, José R. Blanco3, Julià Blanco4, Vicente Boix5, José L. Casado6, Juan C. López-Bernaldo de Quirós7, Josep M. Llibre8

1Unit of Infectious Diseases, Hospital Universitario de Valme, Seville, Spain

2AIDS Immunopathogenesis Unit, Instituto de Salud Carlos III, Madrid, Spain

3Division of Infectious Diseases. Hospital San Pedro-CIBIR. Logroño, Spain

4Fundació IrsiCaixa, Institut Germans Trias i Pujol, Badalona, Spain

5Unit of Infectious Diseases. Hospital General de Alicante. Alicante, Spain

6Department of Infectious Diseases, Hospital Ramón y Cajal, Madrid, Spain

7Unit of Infectious Diseases, Hospital General Gregorio Marañón, Madrid, Spain

8Fundació Lluita contra la SIDA, Hospital Universitari Germans Trias i Pujol, Badalona, Spain

*Corresponding Author:
Dr. Juan A. Pineda
Unidad Clínica de Enfermedades Infecciosas
Hospital Universitario de Valme, Avda
Bellavista s/n. 41014-Seville, Spain
Tel: +34 955015864
Fax: +34 955015795
E-mail: [email protected]

Received Date: January 18, 2011; Accepted Date: February 24, 2011; Published Date: February 25, 2011

Citation: Pineda JA, Alcamí J, Blanco JR, Blanco J, Boix V, et al. (2011) Hot Immunological Topics in HIV Infection. J AIDS Clinic Res 2:118. doi:10.4172/2155-6113.1000118

Copyright: © 2011 Pineda JA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Incomplete immune reconstitution and persistent immune system hyperactivation in spite of highly active antiretroviral therapy continue to be a challenge. Both facts may lead to an increased risk for AIDS-defining and non AIDS-defining clinical conditions and may also promote atherogenesis and liver fibrogenesis in HIV and hepatitis C virus-coinfected patients. In this article, the use of new markers to assess immune reconstitution and immune activation and the incidence and clinical consequences of immunediscordant response to antiretroviral therapy are addressed. Likewise, the impact of immune dysfunction on atherogenesis and liver fibrogenesis are reviewed. Finally, it is discussed whether therapy with drugs belonging to the family of CCR5 inhibitors may provide additional immunological benefit in HIV-infected patients.


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