alexa
Reach Us +44-1647-403003
Complete Pathologic Response in Advanced Primary Gastric Signet-Ring Cell Carcinoma: A Case Report | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Complete Pathologic Response in Advanced Primary Gastric Signet-Ring Cell Carcinoma: A Case Report

Yousra Akasbi1*, Samia Arifi1, Abdelmalek Ousadden2, Siham Tizniti3, Afaf Amarti4 Khalid Ait Taleb2 and Omar EL Mesbahi1

1Medical Oncology unit, Hassan II University Hospital, Fez, Morocco

2Surgery Department, Hassan II University Hospital, Fez, Morocco

3Radiology Department, Hassan II University Hospital, Fez, Morocco

4Pathology Department, Hassan II University Hospital, Fez, Morocco

*Corresponding Author:
Dr. Yousra Akasbi
Medical Oncology unit
Hassan II University Hospital
Fez, Morocco
Tel : +212667624156
E-mail: [email protected]

Received date: December 28, 2010; Accepted date: February 17, 2011; Published date: February 21, 2011

Citation: Akasbi Y, Arifi S, Ousadden A, Tizniti S, Amarti A, et al. (2011) Complete Pathologic Response in Advanced Primary Gastric Signet-Ring Cell Carcinoma: A Case Report. J Cancer Sci Ther 3: 076-078. doi: 10.4172/1948-5956.1000062

Copyright: © 2011 Akasbi Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Gastric signet ring cell carcinoma (SRC) is a poorly differentiated adenocarcinoma in which the tumour cells invade singly or in small groups. The incidence of SRC has been reported in china as 13.9% (662 patients of 4,759) [1]. It is reported to occur more frequent among women and young patients. A regimen of epirubicin, cisplatin, and infused fluorouracil (ECF) improves survival among patients with incurable locally advanced or metastatic gastric adenocarcinoma. Case presentation: A 38-year-old female presented with a 3 weeks history of epigastralgia. Her medical history was unremarkable. The endoscopic findings of the stomach revealed an infiltrative lesion, which the guided biopsy yielded a positive pathologic diagnosis of signet ring cell carcinoma. Diagnostic imaging with an abdominal computed tomography (CT) scan revealed a gastric thickening, with lymph nodes. Induction chemotherapy was recommended, based on 6 cycles of ECX (Epirubicin 50 mg/m2, Cisplatin 60 mg/m2, Capecitabine 625 mg/m2). The total gastrectomy specimen showed a pathological complete response. The patient, who is always followed in consultation, is in complete remission 19 months after the diagnosis Conclusion: SRC is a distinctive histological type of gastric cancer. The ECX or EOX (epirubicin, oxaliplatine, capecitabine) remains the standard treatment of advanced primary gastric signet-ring cell carcinoma. Our case illustrates a complete pathologic response to ECX, which confirmed the effectiveness of this protocol on this histology.

 

Keywords

Share This Page
Top