alexa
Reach Us +44-7482-864460
Physiological and Pathological Roles of Aldose Reductase in Schwann Cells | OMICS International | Abstract
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Mini Review

Physiological and Pathological Roles of Aldose Reductase in Schwann Cells

Kazunori Sango1*, Koichi Kato2, Masami Tsukamoto1,3, Naoko Niimi1, Kazunori Utsunomiya3 and Kazuhiko Watabe4

1Laboratory of Peripheral Nerve Pathophysiology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan

2Laboratory of Medicine, Aichi Gakuin University School of Pharmacy, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan

3Division of Diabetes, Metabolism & Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan

4ALS/Neuropathy Project, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan

Corresponding Author:
Kazunori Sango, MD, Ph.D
Laboratory of Peripheral Nerve Pathophysiology
Department of Sensory and Motor Systems
Tokyo Metropolitan Institute of Medical Science
2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
Tel: 81-3-6834-2359
Fax: 81-3-5316-3150
E-mail: [email protected]

Received Date: December 17, 2013; Accepted Date: January 20, 2014; Published Date: January 27, 2014

Citation: Sango K, Kato K, Tsukamoto M, Niimi N, Utsunomiya K, et al. (2014) Physiological and Pathological Roles of Aldose Reductase in Schwann Cells. J Mol Genet Med S1:012. doi:10.4172/1747-0862.S1-012

Copyright: © 2014 Sango K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aldose reductase (AR), the first enzyme in the polyol pathway, is predominantly localized to Schwann cells in the peripheral nervous system (PNS). The exaggerated glucose flux into the pathway via AR in Schwann cells under diabetic conditions is thought to be a major contributing factor in the pathogenesis of diabetic neuropathy, and the restoring effects of AR inhibitors on the neurological symptoms of experimental diabetic animals and patients with diabetes have been investigated. In contrast, however, much less attention has been paid to the physiological functions of AR in the PNS and other tissues (i.e. osmoregulation, aldehyde detoxification, and steroid and catecholamine metabolism). In this paper, we focus on the functional significance of AR in Schwann cells under normal and diabetic conditions. A spontaneously immortalized adult mouse Schwann cell line IMS32 displays distinct Schwann cell phenotypes and high glucose (30 mM)-induced upregulation of AR expression and accumulation of sorbitol and fructose. This cell line can be a useful model to study the physiological and pathological roles of AR in the PNS, especially the interactions between the polyol pathway and other pathogenetic factors of diabetic neuropathy, and the functional redundancy of AR and other enzymes in aldehyde detoxification.

 

Share This Page
Top