Physiological IMSI (pIMSI) Improves Results Obtained with IMSI in Patients with Idiopathic InfertilityWilding M1*, Coppola G1, Fabozzi G1, Scotto di Frega A1, Di Matteo L1,2, Dale B1
- *Corresponding Author:
- Dr. Martin Wilding
Centro Fecondazione Assistita
Clinica Villa del Sole, Via Manzoni 15
80122 Napoli, Italy
Email: [email protected]
Received date: October 17, 2011; Accepted date: February 09, 2012; Published date: February 15, 2012
Citation: Wilding M, Coppola G, Fabozzi G, Scotto di Frega A, Di Matteo L, et al. (2012) Physiological IMSI (pIMSI) Improves Results Obtained with IMSI in Patients with Idiopathic Infertility. Reproductive Sys Sexual Disord S3:001. doi:10.4172/2161-038X.S3-001
Copyright: © 2012 Wilding M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Study Background: Intracytoplasmic morphology-selected sperm injection (IMSI) is a procedure in which spermatozoa are digitally analysed prior to injection into the oocyte. This increases the chance of selecting a good sperm, but physiological selection is not carried out. Here, we combine physiological pre-selection of spermatozoa with IMSI for patients with idiopathic infertility. Methods: 290 patients, attending for assisted reproduction, were prepared for oocyte retrieval using standard controlled ovarian hyperstimulation protocols. Spermatozoa were preselected for ICSI with either digitalised morphological selection (IMSI) or IMSI combined with hyaluronic acid (HA) pre-selection techniques (pIMSI). Biological and clinical parameters were recorded and the clinical pregnancy rate noted. Results: HA- pre-selection of mature spermatozoa led to a significant increase in pregnancy and implantation rates in patients treated with IMSI. Conclusions: These data suggest that the combination of HA pre-determination of spermatozoa and advanced morphological analysis enables sperm selection on both a physiological and morphological basis and increases the probability of selecting a high quality spermatozoa.