alexa Physiopathology of Pulmonary Hypertension: from Bio-Molecular Mechanism to Target Treatment | OMICS International | Abstract
ISSN: 2329-6925

Journal of Vascular Medicine & Surgery
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Review Article

Physiopathology of Pulmonary Hypertension: from Bio-Molecular Mechanism to Target Treatment

Duong-Quy S1,2*

1Department of Cardio-Respiratory Diseases, Cochin Hospital, Paris Descartes University, France

2Department of Medicine, Penn State Medical College, USA

*Corresponding Author:
Sy Duong-Quy
MD, PhD, Department of Cardio-Respiratory Diseases
Cochin Hospital, Paris Descartes University, France and
Department of Medicine, Penn State Medical College, USA
Tel: +0033679193377
E-mail: [email protected]

Received Date: November 30, 2016; Accepted Date: December 22, 2016; Published Date: December 29, 2016

Citation: Duong-Quy S (2016) Physiopathology of Pulmonary Hypertension: from Bio-Molecular Mechanism to Target Treatment. J Vasc Med Surg 4:294. doi: 10.4172/2329-6925.1000294

Copyright: © 2016 Duong-Quy S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Although the diagnosis and treatment of pulmonary hypertension (PH) is developed constantly in the last decade, PH remains an incurable and difficult to treat disease due to its high life disability and dreadful survival rate. The disease is characterized by sustained vasoconstriction, progressive vascular remodeling, and irreversible right heart dysfunction. The advanced knowledge in physiopathology and classification of PH in recent years is a useful tool helping physicians to improve the choice of target treatment. In addition, the remarkable progresses in understanding the molecular and cellular mechanisms of PH allow to develop new treatments. Actually, new therapeutic molecules have been discovered and their mechanisms of action are better understood and some are in preclinical and clinical trials. Preliminary results of these molecules with benefit effects on pulmonary arterial pressure and systemic hemodynamic gives a new hope for the future.

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