alexa Phytochemical, Anti-inflammatory and Analgesic Studies of the Crude Ethanolic Leaf Extract of Globimetular brounii Van Tieghem (Family: Loranthaceae)
ISSN: 2329-6836

Natural Products Chemistry & Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Phytochemical, Anti-inflammatory and Analgesic Studies of the Crude Ethanolic Leaf Extract of Globimetular brounii Van Tieghem (Family: Loranthaceae)

Atiku I*, Sule MI, Pateh UU, Musa AM, Ya’u J, Sani YM, Hanwa UA, Abdullahi SM, Adamu SA, Lawal EA and Abdulrahman H
Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria
Corresponding Author : Atiku Ibrahim
Department of Pharmaceutical and Medicinal Chemistry
Ahmadu Bello University
Zaria, Nigeria
Tel: 07039605662
E-mail: [email protected]
Received August 31, 2015; Accepted September 30, 2015; Published October 07, 2015
Citation: Atiku I, Sule MI, Pateh UU, Musa AM, Ya’u J, et al. (2015) Phytochemical, Anti-inflammatory and Analgesic Studies of the Crude Ethanolic Leaf Extract of Globimetular brounii Van Tieghem (Family: Loranthaceae). Nat Prod Chem Res 3:193. doi:10.4172/2329-6836.1000193
Copyright: © 2015 Atiku I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google
 

Abstract

Globimetula braunii is a bushy parasitic plant growing on Terminalia catappa, which has a variety of use in African traditional medicine. The leaves of the plant was subjected to preliminary phytochemical analysis, Acute Toxicity studies and analgesic activity using Hot plate and acetic acid induced pain method in mice, while the anti-inflammatory activity was tested using Carrageenan-induced paw oedema in rats. The Phytochemical analysis of the ethanolic leaf extract of Globimetula braunii revealed the presence of Carbohydrate, Steriods, Triterpenes, Tannins, Saponins, Alkaloids and Flavonoids; The LD50 was found to be greater than 5000 mg/kg which shows that the plant extract is relatively safe. The results from the Hot-plate method showed that the extract was statistically significant at (p<0.02 and p<0.01), this shows that there is increase in the latency of pain in the extract compare to standard drug pentazocine (20 mg/kg), while the Acetic acid induced method the extract was statistically significant at (p<0.02) with a percentage of inhibition of 65.5%, 65.2%, and 67.7% at the doses of 12.5 mg/kg, 25 mg/kg, and 50 mg/kg compared with the standard drug piroxicam (10 mg/kg) with a percentage inhibition of 54.3%. The extract was also found to significantly (P<0.05) inhibit oedema at all doses: 250 mg/kg, 500 mg/kg and 1000 mg/kg. This shows that the plant contains phytochemical constituent with analgesic and anti-inflammatory activities.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords