Phytochemical, Antimicrobial, Anthelminthic and Antidiarroheal Activity of Traditional Plant Randia uliginosa Retz
- *Corresponding Author:
- MD Al-Amin
Department of Pharmacy, Jahangirnagar
University, Savar, Dhaka-1342, Bangladesh
E-mail: [email protected]
Received date: October 18, 2016;; Accepted date: November 01, 2016; Published date: November 04, 2016
Citation: Hossain MDS, Al-Amin MD, Hossain MDA, Rana MDS (2016) Phytochemical, Antimicrobial, Anthelminthic and Antidiarroheal Activity of Traditional Plant Randia uliginosa Retz. Nat Prod Chem Res 4:245. doi:10.4172/2329-6836.1000245
Copyright: © 2016 Hossain MDS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present study was designed to evaluate the phytochemical, antimicrobial, antidiarroheal, anthelminthic activity of methanol, chloroform and petroleum ether extract of whole plant of Randia uliginosa Retz. (Family- Rubiaceae) by in vivo and in vitro test. Different crude extracts of Randia uliginosa Retz. have been shown to possess phytoconstituents including carbohydrates, alkaloid, glycosides, steroids, tannins and saponin. Concentration 50 mg/mL of methanol extract showed maximum anthelminthic activity which is comparable to the standard (Piperazine Citrate, 10 mg/mL). Methanol extract of R. uliginosa at a dose of 30 μL/disc showed maximum antimicrobial activity. Significant (p<0.01) level of reduction in fecal dropping was found in 250 mg/kg methanol extract and highly significant at 500 mg/kg methanol extract. The maximum inhibition of defecation 56.98% is observed in 500 mg/kg extract which is comparable to standard Loperamide. These data demonstrate that the plant may contain bioactive compounds possessing antimicrobial, antidiarroheal and anthelminthic activities.