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Phytochemical Characterization and Antioxidative Property ofand#160;<em>Ocimum canum</em>: Effect of Ethanolic Extract of Leaves and Seeds on Basic Immunologic and Metabolic Status of Male Rats | Abstract
ISSN 2476-1966

Journal of Immunobiology
Open Access

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Research Article

Phytochemical Characterization and Antioxidative Property of Ocimum canum: Effect of Ethanolic Extract of Leaves and Seeds on Basic Immunologic and Metabolic Status of Male Rats

Seema Rai*, Hindole Ghosh, and Muddasir Basheer

Department of Zoology, Guru Ghasidas Vishwavidyalaya (Central University), Koni- Bilaspur, India

*Corresponding Author:
Seema Rai
Department of Zoology
Guru Ghasidas Vishwavidyalaya (Central University)
Koni-Bilaspur, India
E-mail: [email protected]

Received Date: December 29, 2015; Accepted Date: April 14, 2016; Published Date: April 24, 2016

Citation: Rai S, Ghosh H, Basheer M (2016) Phytochemical Characterization and Antioxidative Property of Ocimum canum: Effect of Ethanolic Extract of Leaves and Seeds on Basic Immunologic and Metabolic Status of Male Rats. J Immuno Biol 1:108. doi: 10.4172/jib.1000108

Copyright: © 2016 Rai S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The present study was carried out to assess the effect of ethanolic extract of leaves and seeds of Ocimum canum on the hematological parameters (hemoglobin percentage (Hb%), Red Blood Corpuscles (RBC), White Blood Corpuscles (WBC), Differential Leukocyte Counting (DLC)), free radical load on vital organs (brain, testis, liver and kidney) and lymphoid organs (bone marrow, spleen) of male rat. Chemical characterization of leaves and seeds of O. canum showed the presence of volatile oils, flavonoids, carbohydrates, phytosterols, tannins and fixed oils. An oral dose of extracted leave and seeds with 0.05mg/100g body weight daily was given to the rats for 30 days. The hematological parameter showed significant (*p<0.05) increase in Hb%, R.B.C. and basophil was noted. Whereas a significant decrease in the monocyte and eosinolphil was found after the supplementation by ethanolic extract of leaves and seeds and therefore the impact may be said as cell specific. Supplementation of the extract of leave and seeds resulted in the significant decrease of free radical load expressed in Thiobarbituric acid reactive substances (TBARS) in brain. However leaves extract was noted more effective in case of liver, kidney and testis in lowering the free radical load.

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