alexa Phytochemical Evaluation of Anti-Inflammatory Activity of Different Solvents Extracts of Ixora javanica Flowers | OMICS International | Abstract
ISSN: 2329-6836

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Research Article

Phytochemical Evaluation of Anti-Inflammatory Activity of Different Solvents Extracts of Ixora javanica Flowers

Yerragunta Vishwanadham1*, Sunitha D2 and Ramesh A1

1Department of Pharmaceutical Chemistry, Vishni Institute of Pharmaceutical Education and Research, Narsapur, Medak District, Telangana, India

2Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Secunderabad, Telangana, India

*Corresponding Author:
Yerragunta Vishwanadham
Department of Pharmaceutical Chemistry
Vishni Institute of Pharmaceutical Education and Research
Narsapur, Medak District, Telangana India
Tel: +919704697309
E-mail: [email protected]

Received March 31, 2016; Accepted April 21, 2016; Published April 28, 2016

Citation: Vishwanadham Y, Sunitha D, Ramesh A (2016) Phytochemical Evaluation of Anti-Inflammatory Activity of Different Solvents Extracts of Ixora javanica Flowers. Nat Prod Chem Res 4:219. doi:10.4172/2329-6836.1000219

Copyright: © 2016 Vishwanadham Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Ixora javanica (Family Rubiaceae) commonly known as Red Ixora (Nooruvarahalu) in Telugu, Ixora javanica is an ornamental flowering shrub or small tree usually found in tropical south East Asia including southern India. It is mainly used for anti-cancer activity. This study was aimed at providing pharmacological basis for its use in inflammation. Based on this to evaluate the inflammatory activity of Ixora javanica flowers with their phyto constituents. Here using different solvent extract Ixora javanica flowers (Petroleum ether and Ethyl acetate). The Ethyl acetate extract of Ixora javanica flowers showed potent activity comparing with the standard drug diclofenac sodium perhaps due to presence of glycoside and flavonoids present in the flowers. Anti-inflammatory activity by using carrageenan-induced rat paw edema method results indicated that the different extracts of Ixora javanica. Ethyl acetate (EAIJ) extract of at dose of 200 mg/kg showed significant activity (p<0.01) reduction in paw volume, at dose of 200 mg/kg exhibited a marked (P<0.05), inhibition of paw volume, which was comparable to diclofenac (100 mg).

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