alexa Phytochemical Screening and Antimicrobial Activities of Ethanolic Extracts of Moringa oleifera Lam on Isolates of Some Pathogens
ISSN: 1920-4159

Journal of Applied Pharmacy
Open Access

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Research Article

Phytochemical Screening and Antimicrobial Activities of Ethanolic Extracts of Moringa oleifera Lam on Isolates of Some Pathogens

Ibrahim S Abdulkadir1, Idris Abdullahi Nasir2*, Abayomi Sofowora3, Fatima Yahaya4, Auwal Alkasim Ahmad5 and Ismail Adamu Hassan1

1Faculty of Pharmacy, University of Maiduguri, PMB 1069, Maiduguri, Borno state, Nigeria

2Department of Medical Microbiology, University of Abuja Teaching Hospital, PMB 228, Gwagwalada, FCT Abuja, Nigeria

3Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria

4Clinical Laboratory Unit, National Board for Techincal Education, Kaduna State, Nigeria

5Department of Pharmaceutical Services, Ahmadu Bello University Teaching Hospital, PMB 06, Shika Zaria, Kaduna State, Nigeria

*Corresponding Author:
Idris Abdullahi Nasir
Department of Medical Microbiology
University of Abuja Teaching Hospital
PMB 228, Gwagwalada, FCT Abuja, Nigeria
Tel: +2348030522324
E-mail: [email protected]

Received date: August 01, 2015 Accepted date: September 08, 2015 Published date: September 15, 2015

Citation: Abdulkadir IS, Nasir IA, Sofowora A, Yahaya F, Ahmad AA, et al. (2015) Phytochemical Screening and Antimicrobial Activities of Ethanolic Extracts of Moringa oleifera Lam on Isolate of Some Pathogens. J App Pharm 7:203. doi:10.4172/1920-4159.1000203

Copyright: © 2015 Abdulkadir IS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

This work aimed to investigate the phytochemical compositions and in-vitro antimicrobial activities of ethanolic extracts of Moringa oleifera Lam against isolates of Staphylococcus aureus, Escherichia coli and Candida albicans. This involved phytochemical screening and antimicrobial testing of ethanol extracts of Moringa oleifera using basic pharmacognostic procedures and agar well diffusion assay on test pathogens respectively. Alkaloids, flavonoids, saponins and tannins were detected in all extracts with the exception of root which was devoid of saponins and the seeds which contained no tannins. The agar well diffusion assay showed that M. oleifera extracts showed antimicrobial activities against Escherichia coli, Staphylococcus aureus and Candida albicans. Minimum Inhibitory concentrations (MIC) values were (25 mg/ml and 50 mg/ml for the root), (100 mg/ml for the seed) and (50 mg/ ml and 100 mg/ml for the pod) against the three organisms. The leaf extracts was active against Escherichia coli and Staphylococcus aureus but not against Candida albicans. Standard Ciprofloxacin and Ketoconazole (controls) inhibited the test organisms by 100% at 50 mg/ml and 25 mg/ml concentrations respectively. The leaf extracts had the greatest antimicrobial activity against test bacteria (12 mm at 50 mg/ml) while bark extract had the least activity (8 mm at 50 mg/ml). However, only pod extract showed significant antifungal activity (10 mm at 50 mg/ml) while other extracts at the same concentration, showed no antifungal activity. Findings from this study revealed that ethanolic extracts of Moringa oleifera Lam exhibit significant antimicrobial activities on test pathogens and thus suggests need to refine and standardize these extracts as alternative source of antimicrobial medicines.

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