Background: The key reason for failure of an endodontic treatment is incomplete debridement and sterilization because of complex root canal system anatomy which makes elimination of micro-organisms difficult. In spite of the chemical and mechanical debridement of root canals, studies have reported that some microbes like Enterococcus faecalis thrive in periapical lesions, triggering a failure of an endodontic treatment. Considering the vanity, adverse effects and toxicity issues of synthetic medications, the herbal alternatives have been sought for endodontic irrigation. Objectives: To review the current evidence on the efficacy of different plant derivatives against Enterococcus faecalis. Materials and methods: Studies were identified through systematic search of the following electronic databases: PubMed, Web of Science, Scopus, Google Scholar and Cochrane database of systematic reviews. The results from the relevant published literatures are discussed. Summary and Conclusion: The conclusion drawn from in vitro and in vivo studies seems encouraging and as proven in clinical studies, Propolis and Salvadora persica have been proven to be efficacious against Enterococcus faecalis. More laboratory and clinical research is required to assess the safety, efficacy and biocompatibility of other plant extracts, before finally recommending them as alternative endodontic irrigants.