alexa Identification of Binding Affinity of TAP Peptides for Development of Fragment based Vaccine from <em>Long neurotoxin</em> 2 [<em>N. naja</em>] | OMICS International | Abstract
ISSN: 2169-0138

Drug Designing: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Identification of Binding Affinity of TAP Peptides for Development of Fragment based Vaccine from Long neurotoxin 2 [N. naja]

Sherkhane AS and Gomase VS*
The Global Open University Nagaland (TGOUN), India
Corresponding Author : Gomase VS
The Global Open University Nagaland (TGOUN), India
Tel: 91-9987770696
E-mail: [email protected]
Received July 22, 2014; Accepted August 22, 2014; Published August 26, 2014
Citation: Sherkhane AS, Gomase VS (2014) Identification of Binding Affinity of TAP Peptides for Development of Fragment based Vaccine from Long neurotoxin 2 [N. naja]. Drug Des 3:115. doi:10.4172/2169-0138.1000115
Copyright: © 2014 Sherkhane AS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Long neurotoxin 2 protein from the venom of Naja naja shows a great affinity towards acetylcholine receptors, which produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. In this study, we use a cascade SVM based TAPPred method which found 26 High affinity TAP Transporter peptide regions. TAP is heterodimeric transmembrane protein which transports antigenic peptide proteins to the endoplasmic reticulum where it binds to MHC class I molecules, These MHC-peptide complexes will be translocated on the surface of antigen presenting cells (APCs), where they are recognized by T-cell receptors to elicit an immune response. Therefore, prediction of TAP-binding peptides is helpful in identifying the MHC class I-restricted T-cell epitopes and hence helpful in the designing of synthetic peptide vaccine.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7