alexa Pim1 Kinase Cooperates with Hormone Treatment to Promote Bladder and Ureteral Urothelial Hyperplasia
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
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Research Article

Pim1 Kinase Cooperates with Hormone Treatment to Promote Bladder and Ureteral Urothelial Hyperplasia

Maja Narlik-Grassow1, Carmen Blanco-Aparicio1, Yolanda Cecilia1, Marco Perez3, Sandra Muñoz-Galvan3, Marta Cañamero2, Oliver Renner1 and Amancio Carnero3,4*

1Experimental Therapeutics programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

2Biotechnology programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

3Instituto de Biomedicina de Sevilla (IBiS), HUVR/CSIC/Universidad de Sevilla, Sevilla, Spain

4Consejo Superior de Investigaciones Cientificas, Spain

*Corresponding Author:
Amancio Carnero
Instituto de Biomedicina de Sevilla (IBiS), Campus HUVR
Edificio IBIS. Avda. Manuel Siurot s/n. 41013, Sevilla, Spain
Tel: +34955923111
E-mail: [email protected]

Received date: December 17, 2013; Accepted date: January 27, 2014; Published date: February 07, 2014

Citation: Grassow MN, Aparicio CB, Cecilia Y, Perez M, Galvan SM, et al. (2014) Pim1 Kinase Cooperates with Hormone Treatment to Promote Bladder and Ureteral Urothelial Hyperplasia. J Carcinog Mutagen 5:161. doi: 10.4172/2157-2518.1000161

Copyright: © 2014 Grassow MN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The Pim serine/threonine kinases have been shown to be overexpressed in cancer. Elevated levels of Pim1 kinase were demonstrated in human leukemia and lymphomas, as well as in solid tumors such as pancreatic, prostate and bladder cancers, and have been proposed as a prognostic marker. Although the Pim kinases have been identified as oncogenes in transgenic mouse models, they have only weak transforming abilities on their own. However, they have been shown to greatly enhance the ability of other genes or chemical carcinogens to induce tumors. To explore the role of Pim1 in bladder and ureteral urothelial cancer, we generated a conditional Pim1 transgenic mouse model and found that prostate specific antigen-(PSA)-driven Cre expression lead to transgene expression in the bladder upon (testosterone/estrogen) hormone treatment. We then explored the effect of Pim1 overexpression on hormone treatment, either alone or in combination with Pten haploinsufficiency. We found that Pim1 overexpression increased the severity of bladder and ureteral urothelial hyperplasias in both backgrounds, leading to pyelonephritis in transgenic animals. Our data suggest that Pim1 might contribute to progression, rather than initiation, and that the hyperplasias also contribute to the development of pyelonephritis.

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