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Journal of Clinical Trials

Journal of Clinical Trials
Open Access

ISSN: 2167-0870

+44 1478 350008

Abstract

Does the Pandemic Influence Antimicrobial Stewardship? A Historical Control Study before and after Severe Acute Respiratory Syndrome Coronavirus-2 Infection Care in a Teaching Hospital

Junichi Yoshida*, Kenichiro Shiraishi, Tetsuya Kikuchi, Akiko Mataga, Takako Ueno, Takahiro Noda, Kazuhiro Otani and Masao Tanaka

Background: To see whether the COVID-19 pandemic influenced the 3-year use of parenteral antimicrobials, we attempted a historical control study.

Methods: Materials were the electronic medical record on the use of a total of 33 antimicrobials. We compared Antimicrobial Use Density (AUD, total dose/Defined Daily Dose/patient-day × 100) of Pre-pandemic 1 Year (PreY), the first Pandemic Year (Pan1Y), and the second Pandemic Year (Pan2Y). Our antimicrobial team monitored all in-patients and COVID-19 patients underwent clinical pathways with antivirals.

Results: Results showed that in a total of 20,013 patients (7,534, 6,146, and 6,333 for PreY, Pan1Y, and Pan2Y), sepsis-3 was diagnosed in 152, 132, and 283 patients while Clostridioides difficile toxin tests were positive in 17, 5, and 7 patients, respectively. Among patients with COVID-19 (N=622) at a median age of 58 (range, 1-99), 11 (1.8%) died, parenteral antimicrobials were given in 59 patients (9.5%) preceded by bacteriological tests in 48 (81.4%).

Discussion: Comparing before and during the pandemic, parametric analyses showed that the means of total AUD decreased from 16.440 (PreY) to 14.630 (Pan2Y) (P=0.020). Likewise, the means of carbapenems’ AUD showed decrease from 0.773 (PreY) to 0.462 (Pan1Y) but increase into 0.777 (Pan2Y) (P=0.001).

The non-parametric comparison between COVID-19 and other wards showed that the medians of AUD in the COVID-19 wards were significantly (P<0.05) less in 22 out of 33 antimicrobials (66.7%) and in the total AUD.

Conclusion: The COVID-19 pandemic stewardship decreased the total AUD and may have contributed to decrease C. difficile infection. The burden of sepsis-3 may have fluctuated the carbapenems’ use.

Published Date: 2022-07-29; Received Date: 2022-06-29

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