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Pituitary Ganglioneuroma: Case Report and Literature Review | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Case Report

Pituitary Ganglioneuroma: Case Report and Literature Review

Aydin Sav1*, Luis V Syro2, Fabio Rotondo3, Bernd W Scheithauer4,§, Humberto Uribe5, Luis C Penagos6, Eva Horvath3 and Kalman Kovacs3

1Department of Pathology, Acibadem University, School of Medicine, Maltepe, Istanbul, Turkey

2Department of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia

3Department of Laboratory Medicine, St Michael’s Hospital, University of Toronto, Toronto, Ontario, M5B 1W8 Canada

4Department of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA

5Department of Neurosurgery, Clinica SOMA, Medellin, Colombia

6Division of Otolaryngology, Clinica Medellin, Medellin, Colombia

§Died on September 19, 2012

*Corresponding Author:
Aydin Sav
Acibadem University, School of Medicine
Department of Pathology, Kerem Aydinlar Campus
Icerenkoy, Mahallesi, Kayisdagi Cad, 32, Atasehir, Istanbul, Turkey
Tel: 90.216.4512627
Fax: 90.216.3775357
E-mail: [email protected]

Received Date: November 13, 2013; Accepted Date: December 04, 2013; Published Date: December 06, 2013

Citation: Sav A, Syro LV, Rotondo F, Scheithauer BW, Uribe H, et al. (2013) Pituitary Ganglioneuroma: Case Report and Literature Review. J Cytol Histol 5:203. doi: 10.4172/2157-7099.1000203

Copyright: © 2013 Sav A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


We present a case of pituitary ganglioneuroma occurring in a 25 year old woman who presented with headache and hemianopsia. The histologic, immunohistochemical, and ultrastructural features of this tumor support the view that these rare hypothalamic-pituitary tumors are independently functioning neurohormonal units. Immunostaining is strongly positive for neuron-specific enolase (NSE) in all tumor cells and cell processes and for synaptophysin in a few cells and fibers. Few cells closely associated with tumor cells are positive for S100 protein. The cell processes are positive for neurofilament antigen. Ultrastructural analysis documents a spectacular neoplasm of neural derivation. The tumor consists of ganglion cells and areas of neuropil. The most typical tumor cells have relatively lucent spherical nucleus with large nucleolus, and abundant cytoplasm harbors compact sacks of RER membranes studded with ribosomes. Particular emphasis is given to the ultrastructural features which strongly support the functional relationship between the tumor components. It should be kept in mind that unusual and rare ganglionic tumors might show a progressive clinical course and needs surgical intervention as the major part of their treatment whereas ontogenetic and pathogenetic mechanisms taking part still need more work to enlighten pituitary neuronal tumorigenesis.