alexa Pivotal Functions of Plasmacytoid Dendritic Cells in Sy
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis

Wei Cao*
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Corresponding Author : Wei Cao
Department of Immunology, Unit 902
The University of Texas MD Anderson Cancer Center
7455 Fannin St., Houston TX 77054, USA
Tel: 713-563-3315
Fax: 713-563-3357
E-mail: [email protected]
Received March 04, 2014; Accepted April 15, 2014; Published April 22, 2014
Citation: Cao W (2014) Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis. J Clin Cell Immunol 5:212. doi: 10.4172/2155-9899.1000212
Copyright: © 2014 Cao W. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Plasmacytoid dendritic cells (pDCs) were initially identified as the prominent natural type I interferon-producing cells during viral injection. Over the past decade, the aberrant production of interferon α/β by pDCs in response to self-derived molecular entities has been critically implicated in the pathogenesis of systemic lupus erythematosus and recognized as a general feature underlying other autoimmune diseases. On top of imperative studies on human pDCs, the functional involvement and mechanism by which the pDC-interferon α/β pathway facilitates the progression of autoimmunity have been unraveled recently from investigations with several experimental lupus models. This article reviews correlating information obtained from human in vitro characterization and murine in vivo studies and highlights the fundamental and multifaceted contribution of pDCs to the pathogenesis of systemic autoimmune manifestation.

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