alexa Plants as Bioreactors- A Review
ISSN: 2379-1764

Advanced Techniques in Biology & Medicine
Open Access

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Plants as Bioreactors- A Review

Mathangi Ganapathy*
Centre for Biotechnology, Anna University, Chennai, Tamil Nadu, India
Corresponding Author : Mathangi Ganapathy
Centre for Biotechnology Anna
University Chennai, Tamil Nadu, India
Tel: 91-9444336040
E-mail: [email protected]
Received December 28, 2015; Accepted January 11, 2016; Published January 18, 2016
Citation: Ganapathy M (2016) Plants as Bioreactors- A Review. Adv Tech Biol Med 4:161. doi:10.4172/2379-1764.1000161
Copyright: © 2016 Ganapathy M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Currently available systems for the commercial production of recombinant subunit vaccines include bacteria, yeasts, insects and mammalian cell cultures. Each of these systems has specific benefits, but overall, their application is limited by insufficient scalability, cost, safety and target integrity. Plant-based production platforms remains attractive as an alternative due to high scalability, cost-effectiveness and greater safety. Vaccines have been developed against viral, bacterial, parasitic and allergenic antigens for human as well as animal use using plant expression systems. Stable integration of transgene into the nuclear or chloroplast genome in many plants (e.g. tobacco, tomato, potato, papaya, carrot) for the production of subunit vaccines have been reported, effective expression has also been achieved by transient expression. Many plant produced recombinant proteins have shown immunogenicity, several have been shown to work effectively in animal models. This review tries to give an update of plant produced recombinant proteins, the future and limitations.

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