alexa Plasma Cell Leukemia Remains Like an Incurable Disease?
ISSN: 2329-6917

Journal of Leukemia
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Case Report

Plasma Cell Leukemia Remains Like an Incurable Disease? A Rare Presentation of an Aggressive Case of Secondary Plasma Cell Leukemia

Alessandra Gabrielly Magalhães1, James Chagas Almeida1, RenataCordeiro de Araujo1, Jaílson Ferreira Silva1,4, Clésia Abreu Figueiredo Brandão2, Paloma Lys de Medeiros3, Jeymesson Raphae1 Cardoso Vieira3, Isvania Maria Serafim da Silva4 and Luiz Arthur Calheiros Leite4*

1Graduate student, Center of Biological Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil

2Hematology and HemotherapyCenter, HEMOAL, AL, Brazil

3Department of Histology and Embryology, Center of Biological Sciences, UFPE, Recife, Pernambuco, Brazil

4Department of Biophysics and Radiobiology, Center of Biological Sciences, UFPE, Recife, PE, Brazil

Corresponding Author:
Luiz Arthur Calheiros
Leite, Laboratory of Cell Biology UFPE
Recife, PE, Brazil
Tel: +55-81-21268535
E-mail: [email protected]

Received Date: May 21, 2014; Accepted Date: Sepetember 10, 2014; Published Date: September 23, 2014

Citation: Alessandra GM, Almeida JG, de Araujo RC, Silva JF, Figueiredo Brandao FA, et al. (2015) Plasma Cell Leukemia Remains Like an Incurable Disease? A Rare Presentation of an Aggressive Case of Secondary Plasma Cell Leukemia. J Leuk (Los Angel) 2:157. doi:10.4172/2329-6917.1000157

Copyright: © 2014 Magalhaes AG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Secondary plasma cell leukemia is an aggressive variant of multiple myeloma characterized by the presence of more than 2×109/L plasma cells on peripheral blood. We reported an unusual presentation of this entity. The diagnosis of secondary plasma cell leukemia was done by cytological and immunophenotypic characteristics of plasma cells. On the blood smear examination was visualized a high number of plasma cells (46.3×109/L) and plasmablastic cells. Conventional chemotherapy and bortezomib regime led to a complete remission, but the patient’s condition deteriorated very quickly and she died of sepsis. The prognosis of secondary plasma cell leukemia remains unfavorable and the early diagnosis needs to be done in order to provide a better choice of treatment and increase the survival of patients with plasma cell leukemia.


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