alexa Plasma Cell Leukemia-Behind a Disguise
ISSN: 2165-7920

Journal of Clinical Case Reports
Open Access

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Case Report

Plasma Cell Leukemia-Behind a Disguise

Bushra Kaleem*
National Institute of Blood Disease, ST 2/A Block 17, Gulshan-e-Iqbal, KDA scheme 24, Karachi, Pakistan
Corresponding Author : Bushra Kaleem
National Institute of Blood Disease
ST 2/A Block 17, Gulshan-e-Iqbal, KDA scheme 24
Karachi, Pakistan
Tel: +92-21-111-120- 140
E-mail: [email protected]
Received April 16, 2015; Accepted May 27, 2015; Published May 29, 2015
Citation: Kaleem B (2015) Plasma Cell Leukemia-Behind a Disguise. J Clin Case Rep 5:533. doi:10.4172/2165-7920.1000533
Copyright: © 2015 Kaleem B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Plasma cell leukemia is a variant form of multiple myeloma with its own unique form of presentation. It may have
a presentation resembling a lymphoproliferative disorder which if not investigated in detail can lead to misdiagnosis
and thus completely different line of investigation. Our patient presented to us with disturbed dietary regimen,
significant weight loss and was a known case of hypothyroidism since 2009 for which he was on medications. At
the other centre, complete blood picture showed bicytopenia with hyperleucocytosis while bone marrow biopsy
performed showed a diagnosis of lymphoproliferative disorder with a morphological diagnosis of Hairy cell leukemia.
At our center, his complete blood count showed bicytopenia with leucocytosis as before but the morphological
examination of his peripheral smear showed the presence of 80% plasma cells. The immunophenotyping showed
CD23(+) and CD56(+) while the immunohistochemistry showed CD23(+), CD56(+) and CD138(+). Cytogenetics
showed the presence of t(4;14) in 5% of the cells examined. Based on the above mentioned investigations, a
diagnosis of Plasma cell leukemia was reached and the patient was placed on a treatment regimen including
Lenalidomide, Bortezumib and Dexamenthasone. His blood counts came within the normal range within a week
of starting the treatment. Bone marrow biopsy accounts for one of the many steps that should be taken to reach a
correct diagnosis. Keeping in mind the variable presentation a disease can show, as many investigative tools should
be undertaken as is clinically and economically possible for reaching at a correct diagnosis and thus the decision of
the eventual treatment plan for the patient.

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