alexa Plasma Exosomes and Drug Metabolic Cytochrome P450 Enzymes
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

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Editorial

Plasma Exosomes and Drug Metabolic Cytochrome P450 Enzymes

Santosh Kumar*
Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN 38163, USA
Corresponding Author : Santosh Kumar
Department of Pharmaceutical Sciences
College of Pharmacy, University of
Tennessee Health Science Center,
881 Madison Ave, Memphis, TN 38163, USA
Tel: 901-448-7157
E-mail: [email protected]
Received January 31, 2015; Accepted February 03, 2015; Published February 09, 2015
Citation: Kumar S (2015) Plasma Exosomes and Drug Metabolic Cytochrome P450 Enzymes. J Drug Metab Toxicol 6:e124. doi: 10.4172/2157-7609.1000e124
Copyright: © 2015 Kumar S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The major drug metabolic enzymes, Cytochromes P450 (CYP), are abundantly present in hepatocytes, and to some extent in other extrahepatic cells such as monocytes. Since these enzymes metabolize the majority of xenobiotics leading to formation of Reactive Oxygen Species (ROS) and some toxic metabolites, hepatocytes and monocytes could produce extracellular vesicles such as exosomes. The exosomes produced by the liver and blood cells eventually secrete into the plasma, which may contain high levels of exosomes containing CYP enzymes. The level of plasma exosomal CYP enzymes may also be induced under certain conditions. Therefore, plasma exosomal CYP may be used as biological markers, as well as biocatalysts for various purposes in medicine, bioremediation, and industrial synthesis. This editorial briefly describes this novel and exciting area of research in the field of exosomes, and their potential as biomarkers and in therapy.

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